Regulatory crosstalk by protein kinases on CFTR trafficking and activity

Farinha, Carlos M.; Swiatecka-Urban, Agnieszka; Brautigan, David L.; Jordan, Peter

Publication

Regulatory crosstalk by protein kinases on CFTR trafficking and activity

2016-01Journal article

dc.contributor.author	Farinha, Carlos M.
dc.contributor.author	Swiatecka-Urban, Agnieszka
dc.contributor.author	Brautigan, David L.
dc.contributor.author	Jordan, Peter
dc.date.accessioned	2016-09-09T13:04:29Z
dc.date.available	2016-09-09T13:04:29Z
dc.date.issued	2016-01
dc.description.abstract	Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a member of the ATP binding cassette (ABC) transporter superfamily that functions as a cAMP-activated chloride ion channel in fluid-transporting epithelia. There is abundant evidence that CFTR activity (i.e., channel opening and closing) is regulated by protein kinases and phosphatases via phosphorylation and dephosphorylation. Here, we review recent evidence for the role of protein kinases in regulation of CFTR delivery to and retention in the plasma membrane. We review this information in a broader context of regulation of other transporters by protein kinases because the overall functional output of transporters involves the integrated control of both their number at the plasma membrane and their specific activity. While many details of the regulation of intracellular distribution of CFTR and other transporters remain to be elucidated, we hope that this review will motivate research providing new insights into how protein kinases control membrane transport to impact health and disease.	pt_PT
dc.description.sponsorship	Work supported by the Portuguese Fundação para a Ciência e Tecnologia (fellowship grant SFRH/BSAB/105741/2014—to CF, grant PTDC/SAU-ORG/119782/2010—to PJ, and centre grant UID/MULTI/04046/2013—to BioISI); Gilead Génese PGG/039/2014 and ERS Romain Pauwels 2012 (to CF); CFF SWIATE14P0 (to AS); NIH NIDDK P30 072506 Basic and Translational Studies of Cystic Fibrosis (P&F to AS).	pt_PT
dc.identifier.citation	Front Chem. 2016 Jan 20;4:1. doi: 10.3389/fchem.2016.00001. eCollection 2016.	pt_PT
dc.identifier.doi	10.3389/fchem.2016.00001	pt_PT
dc.identifier.issn	2296-2646
dc.identifier.uri	http://hdl.handle.net/10400.18/3915
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Frontiers Media	pt_PT
dc.relation.publisherversion	http://journal.frontiersin.org/article/10.3389/fchem.2016.00001/full	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Vias de Transdução de Sinal e Patologias Associadas	pt_PT
dc.subject	Protein Kinase	pt_PT
dc.subject	WNK	pt_PT
dc.subject	CFTR	pt_PT
dc.subject	Membrane Traffic	pt_PT
dc.title	Regulatory crosstalk by protein kinases on CFTR trafficking and activity	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardURI	info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-ORG%2F119782%2F2010/PT
oaire.citation.endPage	11	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	Frontiers in Chemistry	pt_PT
oaire.citation.volume	4	pt_PT
oaire.fundingStream	3599-PPCDT
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
relation.isProjectOfPublication	4c50eaae-97f4-4471-a751-b4a8db9e3c5d
relation.isProjectOfPublication.latestForDiscovery	4c50eaae-97f4-4471-a751-b4a8db9e3c5d