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Early-life exposure to mycotoxins: assessing the risk under the earlyMYCO project

2021-09Conference object Restricted access
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dc.contributor.authorAssunção, R.
dc.contributor.authorMartins, C.
dc.contributor.authorNunes, Baltazar
dc.contributor.authorSilvia, S.
dc.contributor.authorPires, S.M.
dc.contributor.authorAlvito, P.
dc.date.accessioned2021-11-02T15:06:09Z
dc.date.available2021-11-02T15:06:09Z
dc.date.issued2021-09
dc.description.abstractExposure to hazardous chemicals during the first 1000 days of life has been associated to a number of health disorders, e.g. non-communicable diseases. A proper risk assessment built on accurate data assumes particular importance to evaluate the potential impact that early-life exposure could represent in adulthood. Mycotoxins, secondary fungal metabolites, could have harmful effects in humans and animals. Recent studies reported that Portuguese young children are exposed to multiple mycotoxins through food consumption which could constitute a health concern [1]. However, earlier exposure to these compounds remains unexplored. earlyMYCO – Early-life exposure to MYCOtoxins and its impact on health, a national funded project (PTDC/MED-TOX/28762/2017), intends to contribute to clarify this issue evaluating the health effects of early-life exposure of Portuguese mother-and-child pairs to mycotoxins and assessing the associated risk. The associated health risk will be characterized and the health impact assessed combining data from mother-and-child pairs, their exposure to mycotoxins and newly obtained toxicological data. The Estimated Daily Intake (EDI) will be compared with reference dose values. Preliminary results of exposure to mycotoxins through food consumption (cereal-based foods) in young children (≤ 3 years old) revealed a potential adverse health effect for percentiles of intake of aflatoxins above or equal to P50 (corresponding to 0.041 ng/kg body weight/day or higher). Additionally, results also suggest that high levels of exposure to mycotoxins in the early life are more related with processed foods than with breastmilk. Obtained results will contribute to reach an accurate risk assessment framework and to establish and prioritize preventive measures to reduce exposure to chemicals and risk, especially for vulnerable population groups as pregnant women and infants. [1] R. Assunção, et. al., Food and Chemical Toxicology 118, 399–408 (2018).pt_PT
dc.description.sponsorshipThis work was funded by FCT/MCTES through national funds, to earlyMYCO (PTDC/MED-TOX/28762/2017), and CESAM (UIDP/50017/2020+UIDB/50017/2020).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7800
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.subjectMycotoxinspt_PT
dc.subjectEarly-life Exposurept_PT
dc.subjectChemicalspt_PT
dc.subjectPortuguese Young Childrenpt_PT
dc.subjectMicotoxinaspt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectComposição dos Alimentospt_PT
dc.subjectToxicologia dos Alimentospt_PT
dc.subjectAvaliação do Riscopt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectSaúde Humanapt_PT
dc.subjectPortugalpt_PT
dc.titleEarly-life exposure to mycotoxins: assessing the risk under the earlyMYCO projectpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-TOX%2F28762%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.citation.conferencePlace(online)pt_PT
oaire.citation.title4th International Conference on Food Contaminants: Challenges on Early-Life Exposure, 27-28 set 2021pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublication2635814e-db0a-43c5-b745-a2a237efb72e
relation.isProjectOfPublication4e22de31-8fc5-4b15-b980-3fd0edf5515d
relation.isProjectOfPublication0e72e6c8-b610-43e0-931c-8ad275ad6093
relation.isProjectOfPublication.latestForDiscovery2635814e-db0a-43c5-b745-a2a237efb72e

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