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Association of inflammatory mediators with frailty status in older adults: results from a systematic review and meta-analysis

2020-12Journal article Restricted access
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dc.contributor.authorMarcos-Pérez, Diego
dc.contributor.authorSánchez-Flores, María
dc.contributor.authorProietti, Stefania
dc.contributor.authorBonassi, Stefano
dc.contributor.authorCosta, Solange
dc.contributor.authorTeixeira, Joao Paulo
dc.contributor.authorFernández-Tajes, Juan
dc.contributor.authorPásaro, Eduardo
dc.contributor.authorLaffon, Blanca
dc.contributor.authorValdiglesias, Vanessa
dc.date.accessioned2021-04-08T11:12:07Z
dc.date.available2021-04-08T11:12:07Z
dc.date.issued2020-12
dc.description.abstractFrailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors, leading to a higher risk of negative health-related outcomes. "Inflammaging", an age-related state of low-grade chronic inflammation, is characterized by an increased concentration of pro-inflammatory cytokines and acute phase proteins. Inflammaging has been postulated as an underlying mechanism of frailty, and several studies tested the relationship between frailty and concentration of inflammatory mediators. The aim of this systematic review and meta-analysis was to test whether inflammatory mediators are overproduced in frail older adults. Among the 758 articles identified in the literature search, 50 were included in the systematic review, and 39 in the three meta-analyses, i.e., C-reactive protein (CRP), interleukin 6 (IL6), and tumor necrosis factor α. To reduce heterogeneity, meta-analyses were restricted to studies identifying frailty by the Fried et al. [1] [J. Gerontol. A. Biol. Sci. Med. Sci. 56, M146-56] phenotypic criteria. Quantitative analyses measuring the association between frailty and biomarker concentrations showed significant differences when frail subjects were compared to non-frail and pre-frail subjects for CRP and IL6. This work established strong association between inflammatory biomarkers and frailty, confirming the role of age-related chronic inflammation in frailty development.pt_PT
dc.description.sponsorshipThis research was funded by Xunta de Galicia [ED431B 2019/02]; Ministerio de Educación, Cultura y Deporte [BEAGAL18/00142 to V.V, PRX19/00353 to B.L.]; and Deputación Provincial de A Coruña [to D.M.-P. and M.S.-F.].pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGeroscience. 2020 Dec;42(6):1451-1473. doi: 10.1007/s11357-020-00247-4. Epub 2020 Aug 15.pt_PT
dc.identifier.doi10.1007/s11357-020-00247-4pt_PT
dc.identifier.issn2509-2715
dc.identifier.urihttp://hdl.handle.net/10400.18/7670
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs11357-020-00247-4pt_PT
dc.subjectC-reactive Proteinpt_PT
dc.subjectFrailtypt_PT
dc.subjectInflammagingpt_PT
dc.subjectInterleukin 6pt_PT
dc.subjectOlder Adultspt_PT
dc.subjectTumor Necrosis Factor Alphapt_PT
dc.subjectAvaliação do Riscopt_PT
dc.titleAssociation of inflammatory mediators with frailty status in older adults: results from a systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1473pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1451pt_PT
oaire.citation.titleGeroSciencept_PT
oaire.citation.volume42pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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