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First case of confirmed congenital Zika syndrome in continental Africa

2018-10-01Journal article Restricted access
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dc.contributor.authorSassetti, M.
dc.contributor.authorZé-Zé, L.
dc.contributor.authorFranco, J.
dc.contributor.authorCunha, J.D.
dc.contributor.authorGomes, A.
dc.contributor.authorTomé, A.
dc.contributor.authorAlves, M.J.
dc.date.accessioned2019-02-18T11:44:07Z
dc.date.available2019-02-18T11:44:07Z
dc.date.issued2018-10-01
dc.description.abstractBackground: Zika virus has been responsible for recent outbreaks in the western hemisphere with known neurological complications such as microcephaly. This complication has not been previously documented in continental Africa. Methods: Neurological evaluation of the newborn was performed after birth, at one and two months of age. The mother and the newborn sera samples were tested by immunofluorescent assay (IFA; immunoglobulin G [IgG] and IgM) for Zika virus and the presence of Zika virus ribonucleic acid (RNA) was checked by qualitative real-time reverse transcription polymerase chain reaction (RT-PCR) in placenta, blood and urine samples. Results: We report on a newborn, born in Portugal, with microcephaly with confirmed congenital Zika virus infection (Asian lineage) imported from Angola with typical clinical and imaging findings. Conclusions: To our knowledge this is the first report that shows the circulation of the Asian lineage in Angola and the first report of a congenital Zika syndrome in continental Africa.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTrans R Soc Trop Med Hyg. 2018 Oct 1;112(10):458-462. doi: 10.1093/trstmh/try074pt_PT
dc.identifier.doi10.1093/trstmh/try074pt_PT
dc.identifier.issn0035-9203
dc.identifier.urihttp://hdl.handle.net/10400.18/5843
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Press/ Royal Society of Tropical Medicine and Hygienept_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fpubh.2018.00325/full
dc.subjectZika Viruspt_PT
dc.subjectAngolapt_PT
dc.subjectCongenital Zika Syndromept_PT
dc.subjectMicrocephalypt_PT
dc.subjectPortugalpt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titleFirst case of confirmed congenital Zika syndrome in continental Africapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage462pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage458pt_PT
oaire.citation.titleTransactions of The Royal Society of Tropical Medicine and Hygienept_PT
oaire.citation.volume112pt_PT
rcaap.embargofctPolítica editorial da revistapt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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