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First case of confirmed congenital Zika syndrome in continental Africa
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Orientador(es)
Resumo(s)
Background: Zika virus has been responsible for recent outbreaks in the western hemisphere with known
neurological complications such as microcephaly. This complication has not been previously documented in
continental Africa.
Methods: Neurological evaluation of the newborn was performed after birth, at one and two months of age.
The mother and the newborn sera samples were tested by immunofluorescent assay (IFA; immunoglobulin G
[IgG] and IgM) for Zika virus and the presence of Zika virus ribonucleic acid (RNA) was checked by qualitative
real-time reverse transcription polymerase chain reaction (RT-PCR) in placenta, blood and urine samples.
Results: We report on a newborn, born in Portugal, with microcephaly with confirmed congenital Zika virus
infection (Asian lineage) imported from Angola with typical clinical and imaging findings.
Conclusions: To our knowledge this is the first report that shows the circulation of the Asian lineage in Angola
and the first report of a congenital Zika syndrome in continental Africa.
Descrição
Palavras-chave
Zika Virus Angola Congenital Zika Syndrome Microcephaly Portugal Infecções Sistémicas e Zoonoses
Contexto Educativo
Citação
Trans R Soc Trop Med Hyg. 2018 Oct 1;112(10):458-462. doi: 10.1093/trstmh/try074
Editora
Oxford University Press/ Royal Society of Tropical Medicine and Hygiene