Publication
Modulation of protein translation mediated by upstream open reading frames (uORFs) in PERK mRNA
| dc.contributor.author | Fernandes, Rafael | |
| dc.contributor.author | Romão, Luísa | |
| dc.date.accessioned | 2019-02-28T15:35:17Z | |
| dc.date.embargo | 2025-12-31 | |
| dc.date.issued | 2018-11-15 | |
| dc.description.abstract | Objective: PERK is one of the three sensor proteins from the ER that are responsible for inducing the Unfolded Protein Response (UPR) when stress occurs (4). It is also the kinase responsible for phosphorylating eIF2α in these conditions (4). In this work we intended to determine if PERK is regulated at the translational level by uORFs in normal and ER stress conditions, and understand the impact of this regulation for the cell-stress response. | pt_PT |
| dc.description.sponsorship | Work partially supported by UID/MULTI/04046/2013 centre grant from FCT, Portugal (to BioISI). RF is recipient of a fellowship from BioSys PhD programme (Ref SFRH/BD/114392/2016) from FCT, Portugal. | pt_PT |
| dc.description.version | N/A | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/6005 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | PERK mRNA | pt_PT |
| dc.subject | Sensor Proteins | pt_PT |
| dc.subject | Doenças Genéticas | pt_PT |
| dc.subject | Genómica Funcional e Estrutural | pt_PT |
| dc.title | Modulation of protein translation mediated by upstream open reading frames (uORFs) in PERK mRNA | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04046%2F2013/PT | |
| oaire.citation.conferencePlace | Porto, Portugal | pt_PT |
| oaire.citation.title | 22ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 15-17 novembro 2018 | pt_PT |
| oaire.fundingStream | 5876 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | embargoedAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isProjectOfPublication | dc84f768-e6f2-4eea-b294-6c8ebbd1a156 | |
| relation.isProjectOfPublication.latestForDiscovery | dc84f768-e6f2-4eea-b294-6c8ebbd1a156 |