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Modulation of protein translation mediated by upstream open reading frames (uORFs) in PERK mRNA
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Objective: PERK is one of the three sensor proteins from the ER that are responsible for inducing the Unfolded Protein Response (UPR)
when stress occurs (4). It is also the kinase responsible for phosphorylating eIF2α in these conditions (4). In this work we intended
to determine if PERK is regulated at the translational level by uORFs in normal and ER stress conditions, and understand the
impact of this regulation for the cell-stress response.
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PERK mRNA Sensor Proteins Doenças Genéticas Genómica Funcional e Estrutural