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Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional study

2010-05Journal article Open access
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dc.contributor.authorDomingues-Montanari, S.
dc.contributor.authorFernández-Cadenas, I.
dc.contributor.authorDel Rio-Espinola, A.
dc.contributor.authorCorbeto, N.
dc.contributor.authorKrug, T.
dc.contributor.authorManso, H.
dc.contributor.authorGouveia, L.
dc.contributor.authorSobral, J.
dc.contributor.authorMendioroz, M.
dc.contributor.authorFernández-Morales, J.
dc.contributor.authorAlvarez-Sabin, J.
dc.contributor.authorRibó, M.
dc.contributor.authorRubiera, M.
dc.contributor.authorObach, V.
dc.contributor.authorMartí-Fàbregas, J.
dc.contributor.authorFreijo, M.
dc.contributor.authorSerena, J.
dc.contributor.authorFerro, J.M.
dc.contributor.authorVicente, A.M.
dc.contributor.authorOliveira, S.A.
dc.contributor.authorMontaner, J.
dc.date.accessioned2011-09-14T15:17:42Z
dc.date.available2011-09-14T15:17:42Z
dc.date.issued2010-05
dc.description.abstractVariants in the 5-lipoxygenase-activating protein (ALOX5AP) and phosphodiesterase 4D (PDE4D) genes have first been associated with ischemic stroke (IS) through whole-genome linkage screens. However, association studies obtained conflicting results. We aimed to investigate the contribution of selected single nucleotide polymorphisms (SNPs) in these genes for the first time in a large Iberian population.por
dc.identifier.citationCerebrovasc Dis. 2010;29(6):528-37. Epub 2010 Mar 30.por
dc.identifier.issn1015-9770
dc.identifier.otherDOI: 10.1159/000302738
dc.identifier.urihttp://hdl.handle.net/10400.18/172
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherKargerpor
dc.relation.publisherversionhttp://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowFulltext&ArtikelNr=302738&Ausgabe=254017&ProduktNr=224153por
dc.subjectALOX5APpor
dc.subjectSingle nucleotide polymorphismpor
dc.subjectMeta-analysispor
dc.subjectStrokepor
dc.subjectGeneticspor
dc.subjectPDE4Dpor
dc.subjectDoenças Cardio e Cérebro-vascularespor
dc.titleAssociation of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional studypor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage537por
oaire.citation.startPage528por
oaire.citation.titleCerebrovascular Diseasespor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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