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Publication
Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional study
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Advisor(s)
Abstract(s)
Variants in the 5-lipoxygenase-activating protein (ALOX5AP) and phosphodiesterase 4D (PDE4D) genes have first been associated with ischemic stroke (IS) through whole-genome linkage screens. However, association studies obtained conflicting results. We aimed to investigate the contribution of selected single nucleotide polymorphisms (SNPs) in these genes for the first time in a large Iberian population.
Description
Keywords
ALOX5AP Single nucleotide polymorphism Meta-analysis Stroke Genetics PDE4D Doenças Cardio e Cérebro-vasculares
Pedagogical Context
Citation
Cerebrovasc Dis. 2010;29(6):528-37. Epub 2010 Mar 30.