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Carcinogenic liver fluke Opisthorchis viverrini oxysterols detected by LC-MS/MS survey of soluble fraction parasite extract

2013-08-20Journal article Restricted access
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dc.contributor.authorVale, N.
dc.contributor.authorGouveia, M.J.
dc.contributor.authorBotelho, M.
dc.contributor.authorSripa, B.
dc.contributor.authorSuttiprapa, S.
dc.contributor.authorRinaldi, G.
dc.contributor.authorGomes, P.
dc.contributor.authorBrindley, P.J.
dc.contributor.authorCorreia da Costa, J.M.
dc.date.accessioned2014-01-23T18:14:12Z
dc.date.available2014-01-23T18:14:12Z
dc.date.issued2013-08-20
dc.description.abstractLiquid chromatography in tandem mass spectrometry (LC-MS/MS) has emerged as an informative tool to investigate oxysterols (oxidized derivatives of cholesterol) in helminth parasite associated cancers. Here, we used LC-MS/MS to investigate in soluble extracts of the adult developmental stage of Opisthorchis viverrini from experimentally infected hamsters. Using comparisons with known bile acids and the metabolites of estrogens, the LC-MS data indicated the existence of novel oxysterol derivatives in O. viverrini. Most of these derivatives were ramified at C-17, in similar fashion to bile acids and their conjugated salts. Several were compatible with the presence of an estrogen core, and/or hydroxylation of the steroid aromatic ring A, hydroxylation of both C-2 and C-3 of the steroid ring and further oxidation into an estradiol-2,3-quinone.por
dc.identifier.citationParasitol Int. 2013 Dec;62(6):535-42. doi: 10.1016/j.parint.2013.08.001. Epub 2013 Aug 20.por
dc.identifier.issn1383-5769
dc.identifier.otherdoi:10.1016/j.parint.2013.08.001
dc.identifier.urihttp://hdl.handle.net/10400.18/1876
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevier/ Japanese Society of Parasitologypor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1383576913001165#por
dc.subjectBile Acidspor
dc.subjectFlukespor
dc.subjectOpisthorchis Viverrinipor
dc.subjectOxysterolspor
dc.titleCarcinogenic liver fluke Opisthorchis viverrini oxysterols detected by LC-MS/MS survey of soluble fraction parasite extractpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage542por
oaire.citation.startPage535por
oaire.citation.titleParasitology Internationalpor
oaire.citation.volume62(6)por
rcaap.rightsembargoedAccesspor
rcaap.typearticlepor

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