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The Toxicity of Nanomaterials and Legacy Contaminants: Risks to the Environment and Human Health

2023-07-21Publicação periódica Acesso aberto
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dc.contributor.authorReis, Ana Teresa
dc.contributor.authorCosta, Carla
dc.contributor.authorFraga, Sónia
dc.date.accessioned2024-02-02T11:45:25Z
dc.date.available2024-02-02T11:45:25Z
dc.date.issued2023-07-21
dc.descriptionEditorial of Special Issue Toxicity of Nanomaterials and Legacy Contaminants: Risks to the Environment and Human Health.pt_PT
dc.description.abstractNanotechnology and the incorporation of nanomaterials (NM) into everyday products help to solve problems in society and improve the quality of life, allowing for major advances in the technological, industrial, and medical fields. Despite this positive and encouraging side of nanotechnology, the potential risks of NM to human health and the environment, as well as the ethical, legal, and social implications associated with nanotechnology, cannot be disregarded. Indeed, the same characteristics that make NM interesting from a technological application point of view may be undesirable upon their release into the environment. In fact, hundreds of tons of NM are released into the environment every year. The reduced dimensions of NM facilitate their diffusion into and transport through the atmosphere, water, and soil, and as well as their uptake and (bio)accumulation in organisms. Nanotoxicology has emerged as a discipline that seeks to assess the potential risk of NM, integrating knowledge and resources from material science, biology, toxicology, and analytical chemistry. Several studies have alerted us to the risks that certain NM represent for the environment and for our health, depending on their persistence and circulation in ecosystems, on the dose and responses of organisms to acute and chronic exposure to these substances, and on the ability of organisms to (bio)accumulate and/or excrete them. However, knowledge of the harmful effects of these contaminants of emerging concern is still insufficient, including mixture effects. Efforts to advance our knowledge on the reactivity of NM and their effects have been made using mostly in vitro and in vivo models; however, in recent years, in silico approaches and quantitative structure–activity relationship (QSAR) modeling have been gaining more attention. Nanotoxicity assessment using in vitro models gathers important information regarding the mechanism(s) of action of NM at the cellular and molecular levels. These models also offer the benefits of reduced costs and ethical concerns over animal welfare (3Rs principle), usually resulting in the faster toxicity screening of chemicals, an advantage considering the increasing number of materials and contaminant combinations to be tested. However, they lack the complexity and metabolic capabilities that in vivo models provide, which is important in identifying the relationship between exposure dose and the occurrence of adverse effects, and in understanding how the body handles NM in terms of their absorption, distribution, metabolism, and excretion (ADME). (...)pt_PT
dc.description.sponsorshipAna Teresa Reis is thankful for the financial support of FCT and FEDER—Fundo Europeu de Desenvolvimento Regional through the COMPETE 2020—POCI, in the framework of the project POCI-01-0145-FEDER-029651, and individual FCT Grant SFRH/BPD/122112/2016. Sónia Fraga acknowledges the funding from the Operational Program for Competitiveness and Internationalization (POCI) through the European Regional Development Funds (FEDER/FNR) and from the Foundation for Science and Technology (FCT) (grant refs. POCI-01-0145-FEDER-031162 and DL-57/INSA-06/2018). The authors also thank FCT/MCTES for the financial support to EPIUnit (UIDB/04750/2020) and ITR (LA/P/0064/2020)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Mol Sci. 2023 Jul 21;24(14):11723.doi: 10.3390/ijms241411723pt_PT
dc.identifier.doi10.3390/ijms241411723pt_PT
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10400.18/9023
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationA novelty study on the human uptake, genotoxicity and immunotoxicity of nanoparticles and legacy contaminants mixtures
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relationLaboratory for Integrative and Translational Research in Population Health
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/24/14/11723pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNanomaterialspt_PT
dc.subjectContaminantspt_PT
dc.subjectToxicitypt_PT
dc.subjectEnvironmentpt_PT
dc.subjectNanotoxicologypt_PT
dc.subjectHuman Healthpt_PT
dc.subjectToxicologiapt_PT
dc.titleThe Toxicity of Nanomaterials and Legacy Contaminants: Risks to the Environment and Human Healthpt_PT
dc.typeperiodical
dspace.entity.typePublication
oaire.awardTitleA novelty study on the human uptake, genotoxicity and immunotoxicity of nanoparticles and legacy contaminants mixtures
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardTitleLaboratory for Integrative and Translational Research in Population Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F122112%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04750%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0064%2F2020/PT
oaire.citation.issue14pt_PT
oaire.citation.startPage11723pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume24pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofct(UIDB/04750/2020) and ITR (LA/P/0064/2020)pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typecontributionToPeriodicalpt_PT
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relation.isProjectOfPublication18ca3cb0-ef66-4dd8-b45e-4cb0654cd7e8
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