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Shorter p53 isoform expression through na Internal Ribosome Entry Site (IRES) in p53 mRNA

2017-11-16Conference object Restricted access
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dc.contributor.authorNeves, Ana Rita
dc.contributor.authorLacerda, Rafaela
dc.contributor.authorMarques-Ramos, Ana
dc.contributor.authorRomão, Luísa
dc.contributor.authorMatsuda, M
dc.contributor.authorCandeias, Marco
dc.date.accessioned2018-03-05T16:36:05Z
dc.date.embargo2025-12-31
dc.date.issued2017-11-16
dc.description.abstractThe tumour suppressor p53 gene is one of the most studied cancer-related genes. So far, many p53 isoforms have been identified either resulting from alternative splicing, alternative translation or alternative promoter usage. It is known that cap-dependent translation is repressed under stress conditions to preserve energy. Therefore, other translational mechanisms are required to keep the synthesis of stress-response proteins. Internal Ribosome Entry Sites (IRESes) were first discovered in viruses, and then observed in eukaryotes, as secondary structures present in RNA that were capable of recruiting ribosomes to the vicinity of an initiation codon inserted in an optimal environment allowing cap-independent translation of mRNAs. Translation of Δ40p53, a p53 isoform, is one example of this non-canonical mechanism due to the presence of an IRES near an alternative initiation codon (AUG40). Here, we will present a new IRES in p53 mRNA, including details on the localization and regulation of this IRES under normal and stress conditions.pt_PT
dc.description.sponsorshipFCT/PTDC/BIM-ONC/4890/2014pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/5169
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectCancerpt_PT
dc.subjectTumour Suppressor p53 Genept_PT
dc.subjectExpressão Génicapt_PT
dc.subjectGenómica Funcional e Estruturalpt_PT
dc.titleShorter p53 isoform expression through na Internal Ribosome Entry Site (IRES) in p53 mRNApt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceCaparica, Portgalpt_PT
oaire.citation.title21ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 16-18 novembro 2017pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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