Publication
Colon cancer cell biology: splicing, signaling and beyond
| dc.contributor.author | Jordan, Peter | |
| dc.date.accessioned | 2020-05-27T12:14:53Z | |
| dc.date.available | 2021-12-01T01:30:12Z | |
| dc.date.issued | 2019-10 | |
| dc.description.abstract | Introduction: In colon cancer distinct genetic subtypes have been described, one of which involves overexpression of RAC1b, a variant generated by alternative splicing. Aberrant splicing is known to occur in cancer and can be caused by mutation in a gene or splicing factor but also represents a dynamic response to oncogene-induced cellular signaling and in this case it may be pharmacologically targeted. Here we explore how signaling pathways are involved in the deregulation of alternative RAC1b splicing in colorectal tumor cells. | pt_PT |
| dc.description.version | N/A | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/6843 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | no | pt_PT |
| dc.subject | Colon Cancer | pt_PT |
| dc.subject | Splicing | pt_PT |
| dc.subject | Signaling | pt_PT |
| dc.subject | RAC1b | pt_PT |
| dc.subject | BRAF | pt_PT |
| dc.subject | Vias de Transdução de Sinal e Patologias Associadas | pt_PT |
| dc.title | Colon cancer cell biology: splicing, signaling and beyond | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Lisboa, Portugal | pt_PT |
| oaire.citation.title | 3rd NMS Symposium on Chronic Diseases and Translational Science, 14-16 October 2019 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |