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Prevalence and incidence of Helicobacter pylori Infection in a healthy pediatric population in the Lisbon area

2011-10Journal article Restricted access
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dc.contributor.authorOleastro, Mónica
dc.contributor.authorPelerito, Ana
dc.contributor.authorNogueira, Paulo
dc.contributor.authorBenoliel, João
dc.contributor.authorSantos, Andrea
dc.contributor.authorCabral, José
dc.contributor.authorLopes, Ana Isabel
dc.contributor.authorRamalho, Paulo
dc.contributor.authorMonteiro, Lurdes
dc.date.accessioned2012-01-12T16:46:09Z
dc.date.available2012-01-12T16:46:09Z
dc.date.issued2011-10
dc.description.abstractBACKGROUND: Helicobacter pylori is mainly acquired in childhood. Although adult studies reported a high prevalence of H. pylori infection in Portugal, the actual rate in children remains unknown. This study aimed to determine the prevalence and the incidence of H. pylori infection in an asymptomatic pediatric population of the Lisbon area and to correlate prevalence with sociodemographic determinants. MATERIALS AND METHODS: Helicobacter pylori infection was determined by stool antigen test in 844 asymptomatic children (age 0-15 years; 49.4% boys). For the incidence study, H. pylori-negative children in the prevalence study were followed-up every 6 months over a 3-year period. RESULTS: The global prevalence of H. pylori infection was 31.6%, increasing with age (19.9, 37.0 and 51.5%, in age groups 0-5, 6-10, and 11-15, respectively), but was similar among genders (34.5% in boys and 28.4% in girls). Older age and attendance of nursery/kindergarten during preschool constituted independent risk factors. The overall estimated incidence was 11.6 per 100 child-years (CY). Although 47.5% of children acquired H. pylori infection before 5 years of age, the mean age of acquisition was 6.3. The incidence of infection was similar among the three age groups (11.5, 13.0, and 10.5 per 100 CY, in age groups 0-5, 6-10, and 11-15, respectively). CONCLUSIONS: The prevalence of H. pylori infection in the Portuguese pediatric population is still high. Although this study confirmed that the highest acquisition rate occurs at young age, it showed that in high-prevalence populations, older children can also acquire H. pylori infection at a rate similar to that of young children.por
dc.description.sponsorshipFCTpor
dc.identifier.citationHelicobacter. 2011 Oct;16(5):363-72. Epub 2011 Sep 19por
dc.identifier.issnESSN: 1083-4389
dc.identifier.otherdoi: 10.1111/j.1523-5378.2011.00858.x.
dc.identifier.urihttp://hdl.handle.net/10400.18/372
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherBlackwell Publishing Ltapor
dc.relationFCT research Grant 35883 ⁄ 99por
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/j.1523-5378.2011.00858.x/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+14+Jan+from+10-12+GMT+for+monthly+maintenancepor
dc.subjectHelicobacter pyloripor
dc.subjectPrevalencepor
dc.subjectIncidencepor
dc.subjectPediatricpor
dc.subjectStool antigenspor
dc.subjectInfecções Gastrointestinaispor
dc.titlePrevalence and incidence of Helicobacter pylori Infection in a healthy pediatric population in the Lisbon areapor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage372por
oaire.citation.startPage363por
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

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