Toxicity of different classes of manufactured nanomaterials in rat alveolar epithelial RLE-6TN cells

Brandão, Fátima; Fraga, Sónia; Costa, Carla; Silva, Susana; Bessa, Maria João; Haase, Andrea; Teixeira, João Paulo

http://hdl.handle.net/10400.18/6083

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Abstract(s)

The rapid development of manufactured nanomaterials (MNMs) and their increased use for commercial and industrial applications lead to the urgent need of the toxicological assessment of their potential toxicity. Thus, this study evaluated the cyto- and genotoxicity of a panel of MNMs, including SiO2 nanoparticles (NPs), graphene oxide and nano-sized pigments in rat alveolar epithelial cells (RLE-6TN), a primary target during inhalation exposure.