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Molecular regulation of the plasma membrane retention of disease-related chloride channels CFTR and NKCC2
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Orientador(es)
Resumo(s)
Three disease-related chloride transport proteins, CFTR (in cystic fibrosis (CF) or
chronic obstructive pulmonary disease (COPD)), NKCC2 and KCC3 (in kidney function and
hypertension), were found to specific targets for protein kinase Syk which phosphorylates a
specific tyrosine residue in each channel. Tyrosine phosphorylation downregulates the amount
of CFTR [1] present at the plasma membrane and a better understanding of this process may
reveal novel therapeutic options for CF patients. Thus, we determined the cellular adaptor
proteins able to recognize the phospho-tyrosine modification and mediate traffic to the plasma
membrane.
Descrição
Palavras-chave
Vias de Transdução de Sinal e Patologias Associadas WNK Protein Kinases Fibrose Quística Hipertensão Arterial