Molecular regulation of the plasma membrane retention of disease-related chloride channels CFTR and NKCC2

Loureiro, Claudia; Matos, P; Clarke, Luka; Jordan, Peter

http://hdl.handle.net/10400.18/5192

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Abstract(s)

Three disease-related chloride transport proteins, CFTR (in cystic fibrosis (CF) or chronic obstructive pulmonary disease (COPD)), NKCC2 and KCC3 (in kidney function and hypertension), were found to specific targets for protein kinase Syk which phosphorylates a specific tyrosine residue in each channel. Tyrosine phosphorylation downregulates the amount of CFTR [1] present at the plasma membrane and a better understanding of this process may reveal novel therapeutic options for CF patients. Thus, we determined the cellular adaptor proteins able to recognize the phospho-tyrosine modification and mediate traffic to the plasma membrane.