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Advisor(s)
Abstract(s)
O crómio hexavalente (Cr ( VI ) ) é um agente cancerígeno para o ser humano,
estando na origem de cancro no pulmão. As indústrias em que
ocorre exposição ao Cr ( VI ) incluem a produção, utilização e soldadura
de metais e ligas contendo crómio. O presente estudo tem como objetivo
analisar os resultados de monitorização ambiental e biológica
da exposição profissional ao Cr ( VI ) no âmbito da participação portuguesa
na Iniciativa Europeia de Biomonitorização Humana (HBM4EU ).
O estudo envolveu 50 trabalhadores expostos a Cr ( VI ) e 27 controlos.
Realizou-se monitorização ambiental, por amostragem pessoal do ar,
para estudar a exposição a Cr ( VI ) e monitorização biológica ( urina e
eritrócitos ). Os resultados obtidos neste estudo sugerem que os pintores
são o grupo com maior exposição externa e interna ao Cr ( VI ). Os
trabalhadores dos banhos eletrolíticos apresentam uma exposição relevante,
quando comparada com o valor limite de exposição de 0,005
mg/m3 apesar de consideravelmente inferior à dos pintores. Os resultados
das medições de Cr-U pós-turno, quando agregados ao nível do
grupo profissional apresentaram boa correlação ( ρ=0,63 ) com a fração
respirável de Cr ( VI ) no ar, apoiando a utilização do Cr-U para a biomonitorização
da exposição ao Cr ( VI ) nos locais de trabalho. A diferente
cinética dos indicadores biológicos estudados pode ser a razão
pela qual não se verificou uma boa correlação entre Cr-U pós-turno e
Cr-RBC ( ρ<0,5 ), no entanto podem fornecer informação complementar
relevante para a prevenção.
Hexavalent chromium (Cr(VI)) is a human carcinogen, causing lung cancer. Industries where exposure to Cr(VI)occurs include the production, use and welding of metals and alloys containing chromium. The present study aims to analyze the results of environmental and biological monitoring of occupational exposure to Cr(VI) as part of the Portuguese participation in the European Human Biomonitoring Initiative (HBM4EU). The study involved 50 workers exposed to Cr(VI) and 27 controls. Environmental monitoring was performed by personal air sampling to study Cr(VI) exposure and biological monitoring (urine and erythrocytes). The results obtained in this study suggest that painters are the group with the highest external and internal Cr(VI) exposure. The electrolyte bathers have a relevant exposure compared to the exposure limit value of 0.005 mg/m3, although considerably lower than the painters. The results of the post-shift measurements of Cr-U, when aggregated at the occupational g roup l evel s howed a g ood c orrelation ( ρ=0.63) w ith t he r espirable fraction of Cr(VI) in air, supporting the use of Cr-U for biomonitoring of Cr(VI) exposure in workplaces. The different kinetics of the biological indicators studied may be the reason why there was not a good correlation between post-transmission Cr-U and Cr-RBC (ρ<0.5), however they may provide complementary information relevant for prevention.
Hexavalent chromium (Cr(VI)) is a human carcinogen, causing lung cancer. Industries where exposure to Cr(VI)occurs include the production, use and welding of metals and alloys containing chromium. The present study aims to analyze the results of environmental and biological monitoring of occupational exposure to Cr(VI) as part of the Portuguese participation in the European Human Biomonitoring Initiative (HBM4EU). The study involved 50 workers exposed to Cr(VI) and 27 controls. Environmental monitoring was performed by personal air sampling to study Cr(VI) exposure and biological monitoring (urine and erythrocytes). The results obtained in this study suggest that painters are the group with the highest external and internal Cr(VI) exposure. The electrolyte bathers have a relevant exposure compared to the exposure limit value of 0.005 mg/m3, although considerably lower than the painters. The results of the post-shift measurements of Cr-U, when aggregated at the occupational g roup l evel s howed a g ood c orrelation ( ρ=0.63) w ith t he r espirable fraction of Cr(VI) in air, supporting the use of Cr-U for biomonitoring of Cr(VI) exposure in workplaces. The different kinetics of the biological indicators studied may be the reason why there was not a good correlation between post-transmission Cr-U and Cr-RBC (ρ<0.5), however they may provide complementary information relevant for prevention.
Description
Keywords
Crómio Hexavalente Cr (VI) Biomonitorização Humana Exposição Humana Saúde Ocupacional Genotoxicidade Ambiental Ar e Saúde Ocupacional
Pedagogical Context
Citation
Boletim Epidemiológico Observações. 2022;11(Supl 14):31-39
Publisher
Instituto Nacional de Saúde Doutor Ricardo Jorge, IP
