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Second-hand smoke exposure modulates plasma proteins linked to detoxification, inflammation and atherothrombosis

2025-11-08Artigo científico Acesso aberto
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datacite.subject.fosCiências Naturais::Ciências Biológicas
dc.contributor.authorNeves, Sofia
dc.contributor.authorPacheco, Solange A.
dc.contributor.authorVaz, Fátima
dc.contributor.authorValentim-Coelho, Cristina
dc.contributor.authorSaraiva, Joana
dc.contributor.authorJames, Peter
dc.contributor.authorSimões, Tânia
dc.contributor.authorPenque, Deborah
dc.date.accessioned2026-01-20T10:37:28Z
dc.date.available2026-01-20T10:37:28Z
dc.date.issued2025-11-08
dc.description.abstractChronic exposure to second-hand smoke (SHS) contributes to the development of health issues, including cancer and cardiovascular diseases. Molecular mechanisms underlying SHS-related diseases remain poorly understood, highlighting the need for reliable risk assessment biomarkers. Herein, we demonstrate that the plasma proteome of individuals exposed to SHS undergoes significant modulation. Butyrylcholinesterase (BChE) and Vitamin D-binding protein (GC) that are involved in the physiological response to circulating toxic substances, as well as key mediators of systemic inflammation, including Complement C1r subcomponent (C1R), Complement C1q subcomponent subunit C (C1QC), Histidine-rich glycoprotein (HRG), and Vitamin K-dependent protein S (PROS1), were found to be significantly modulated in SHS-exposed individuals. Moreover, strong indicators of a pro-atherothrombotic response such Apolipoprotein A-IV (APOA4) and Alpha-2-antiplasmin (SERPINF2), were also differentially expressed. These findings provide novel insights into the biological pathways linking SHS-exposure to cardiovascular risks, and suggest a panel of candidate proteins with potential utility as SHS-risk assessment biomarkers.eng
dc.description.abstractHighlights: - Plasma proteome is modulated upon SHS exposure. - SHS triggers a proinflammatory and autoimmune response. - SHS may induce a pro-atherothrombotic state. - BChE and GC are candidate biomarkers for SHS response. - APOA4 and SERPINF2 may indicate SHS-related cardiovascular risk.eng
dc.description.sponsorshipThis work was supported by the Calouste Gulbenkian Foundation, Rede Nacional de Espectrometria de Massa (RNEM), National Institute of Health Doctor Ricardo Jorge, and UID/04923 - Comprehensive Health Research Centre. Sofia Neves (SFRH/BD/82648/2011), Solange A. Pacheco (SFRH/BD/74857/2010), Cristina Valentim-Coelho (SFRH/BD/133511/2017) and Joana Saraiva (2022.14435.BD) were granted with PhD fellowships from Fundação para a Ciência e a Tecnologia – FCT.
dc.identifier.citationEnviron Toxicol Pharmacol. 2025 Dec:120:104864. doi: 10.1016/j.etap.2025.104864. Epub 2025 Nov 8
dc.identifier.doi10.1016/j.etap.2025.104864
dc.identifier.eissn1872-7077
dc.identifier.issn1382-6689
dc.identifier.urihttp://hdl.handle.net/10400.18/10717
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationCOVID-19 Vaccination - Emerging role of Red Blood Cells as immunomodulators
dc.relationSFRH/BD/82648/2011
dc.relationSFRH/BD/74857/2010
dc.relationSFRH/BD/133511/2017
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S138266892500239X?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAtherosclerosis
dc.subjectInflammation
dc.subjectPlasma
dc.subjectSecond-Hand Smoke
dc.subjectThrombosis
dc.subjectShotgun Proteomics
dc.subjectGenómica Funcional e Estrutural
dc.titleSecond-hand smoke exposure modulates plasma proteins linked to detoxification, inflammation and atherothrombosiseng
dc.typejournal article
dcterms.referenceshttps://www.sciencedirect.com/science/article/pii/S138266892500239X?via%3Dihub#ec0005
dcterms.referenceshttps://www.sciencedirect.com/science/article/pii/S138266892500239X?via%3Dihub#ec0010
dcterms.referenceshttps://www.sciencedirect.com/science/article/pii/S138266892500239X?via%3Dihub#ec0015
dcterms.referenceshttps://www.sciencedirect.com/science/article/pii/S138266892500239X?via%3Dihub#ec0020
dcterms.referenceshttps://www.sciencedirect.com/science/article/pii/S138266892500239X?via%3Dihub#ec0025
dspace.entity.typePublication
oaire.awardTitleCOVID-19 Vaccination - Emerging role of Red Blood Cells as immunomodulators
oaire.awardURIhttp://hdl.handle.net/10400.18/10716
oaire.citation.startPage104864
oaire.citation.titleEnvironmental toxicology and pharmacology
oaire.citation.volume120
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
relation.isProjectOfPublication3c67c2b0-43d0-4eb7-a0c3-22209a9ea4f5
relation.isProjectOfPublication.latestForDiscovery3c67c2b0-43d0-4eb7-a0c3-22209a9ea4f5

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