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Publicação
Second-hand smoke exposure modulates plasma proteins linked to detoxification, inflammation and atherothrombosis
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Orientador(es)
Resumo(s)
Chronic exposure to second-hand smoke (SHS) contributes to the development of health issues, including cancer and cardiovascular diseases. Molecular mechanisms underlying SHS-related diseases remain poorly understood, highlighting the need for reliable risk assessment biomarkers. Herein, we demonstrate that the plasma proteome of individuals exposed to SHS undergoes significant modulation. Butyrylcholinesterase (BChE) and Vitamin D-binding protein (GC) that are involved in the physiological response to circulating toxic substances, as well as key mediators of systemic inflammation, including Complement C1r subcomponent (C1R), Complement C1q subcomponent subunit C (C1QC), Histidine-rich glycoprotein (HRG), and Vitamin K-dependent protein S (PROS1), were found to be significantly modulated in SHS-exposed individuals. Moreover, strong indicators of a pro-atherothrombotic response such Apolipoprotein A-IV (APOA4) and Alpha-2-antiplasmin (SERPINF2), were also differentially expressed. These findings provide novel insights into the biological pathways linking SHS-exposure to cardiovascular risks, and suggest a panel of candidate proteins with potential utility as SHS-risk assessment biomarkers.
Highlights: - Plasma proteome is modulated upon SHS exposure. - SHS triggers a proinflammatory and autoimmune response. - SHS may induce a pro-atherothrombotic state. - BChE and GC are candidate biomarkers for SHS response. - APOA4 and SERPINF2 may indicate SHS-related cardiovascular risk.
Highlights: - Plasma proteome is modulated upon SHS exposure. - SHS triggers a proinflammatory and autoimmune response. - SHS may induce a pro-atherothrombotic state. - BChE and GC are candidate biomarkers for SHS response. - APOA4 and SERPINF2 may indicate SHS-related cardiovascular risk.
Descrição
Palavras-chave
Atherosclerosis Inflammation Plasma Second-Hand Smoke Thrombosis Shotgun Proteomics Genómica Funcional e Estrutural
Contexto Educativo
Citação
Environ Toxicol Pharmacol. 2025 Dec:120:104864. doi: 10.1016/j.etap.2025.104864. Epub 2025 Nov 8
Editora
Elsevier