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Systematic Literature Reviews as a tool to develop Adverse Outcome Pathway landscapes in Nanotoxicology: case study of ingested Titanium dioxide nanomaterials

2020-11-15Conference object Open access
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dc.contributor.authorRolo, Dora
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorSilva, Maria João
dc.contributor.authorLouro, Henriqueta
dc.date.accessioned2021-03-13T15:38:22Z
dc.date.available2021-03-13T15:38:22Z
dc.date.issued2020-11-15
dc.description.abstractWorldwide, Titanium dioxide nanomaterials are one of the most frequently applied nanomaterial as food additive, pharmaceuticals and toothpastes. Many studies addressed their potential adverse effects considering the nanomaterials primary physicochemical characteristics. However, surrounding matrix can affect their properties and consequently the secondary features may be more relevant for determining the toxicological outcome. In this regard, further research is needed. In fact, the potential of Ingested TiO2 nanomaterials (Ing-TiO2) to cause undesirable effects on human life is still unknown. Of major concern is their potential to lead to genotoxicity that may contribute to cancer. A valuable tool in predictive nanotoxicology is the establishment of Adverse Outcome Pathways (AOPs) landscapes. However, there is a lack of systematic approaches to assess this issue. A systematic literature review (SLR), that integrates information produced on this topic and provides data for a standardized assessment of the evidence, is necessary. The goal of this study was to conduct a SLR evaluating the genotoxicity of Ing-TiO2, for identifying key cellular and molecular events leading to adverse health outcomes in order to guide future research needs on the assessment of potential AOPs. It is expected that a framework of AOPs for Ing-TiO2, that describes a sequence of causally linked events at different levels of biological organization leading to adverse health effects, may contribute to support risk assessment based on mechanistic reasoning. Strengths and limitations of this strategy are discussed in view of their usefulness as a tool for risk assessment.pt_PT
dc.description.sponsorshipFunded by FCT/MCTES through national funds (PIDDAC), PTDC/SAU-PUB/29481/2017 and co-funded by ToxOmics (UIDB/00009/2020) and CESAM (UIDP/50017/2020+UIDB/50017/2020).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRolo D., Assunção R., Silva M.J., Louro H. Systematic Literature Reviews as a tool to develop Adverse Outcome Pathway landscapes in Nanotoxicology: case study of ingested Titanium dioxide nanomaterials. 2nd International Online-Conference (IOCN 2020). 15-30 November 2020. Online poster communication.pt_PT
dc.identifier.doi10.3390/IOCN2020-08533pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7448
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCentre for Toxicogenomics and Human Health
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relation.publisherversionhttps://sciforum.net/paper/view/conference/8533pt_PT
dc.subjectNanomaterialspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectIngested Nanomaterialspt_PT
dc.subjectAdverse Outcome Pathwayspt_PT
dc.subjectSystematic Literature Reviewpt_PT
dc.subjectNanotoxicologypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectToxicologiapt_PT
dc.titleSystematic Literature Reviews as a tool to develop Adverse Outcome Pathway landscapes in Nanotoxicology: case study of ingested Titanium dioxide nanomaterialspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F29481%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.citation.conferencePlace(online)pt_PT
oaire.citation.title2nd International Online-Conference on Nanomaterials (IOCN), 15-30 November 2020pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSilva
person.familyNameLouro
person.givenNameMaria Joao
person.givenNameHenriqueta
person.identifier157627
person.identifier.ciencia-id7710-643D-97A3
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0002-6060-0716
person.identifier.orcid0000-0001-9744-7332
person.identifier.scopus-author-id55944437600
person.identifier.scopus-author-id6507971479
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com página web do editor da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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