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Lung abscess due to Neisseria meningitidis serogroup X-unexpected virulence of a commensal resulting from putative serogroup B capsular switching

2020-12Journal article Restricted access
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dc.contributor.authorBettencourt, Célia
dc.contributor.authorNunes, Alexandra
dc.contributor.authorCorreia, Ana Maria
dc.contributor.authorGomes, João Paulo
dc.contributor.authorSimões, Maria João
dc.date.accessioned2021-03-03T15:41:44Z
dc.date.available2021-07-14T00:30:14Z
dc.date.issued2020-12
dc.description.abstractTo report the first case of a lung abscess caused by Neisseria meningitidis (Nm) and to genetically characterize the rare underlying capsule switching event. The strain (PT NmX) was subjected to whole genome sequencing, and a comparative gene-by-gene analysis was performed based on 1605 N. meningitidis core loci that constitute the MLST core-genome scheme (cgMLST) V1.0. All ~ 9,600 genomes available on Neisseria PubMLST (until 30th November 2019) from all serogroups were used to better identify the genome make-up of the PT NmX strain. This strain was found to be highly divergent from other NmX reported worldwide and to belong to a new sequence type (ST-14273), with the finetype X: P1.19,15-1:F5-2. Moreover, it revealed a closer genetic proximity to strains from serogroup B than to other serogroups, suggesting a genome backbone associated with serogroup B, while it presents a capsule synthesis region derived from a NmX strain. We describe a new hybrid NmB/X isolate from a noninvasive meningococcal infection, causing lung abscess. Despite capsular switching events involving serogroup X are rare, it may lead to the emergence of pathogenic potential. Studies should continue to better understand the molecular basis underlying Neisseria strains' ability to spread to body compartments other than the tissues for which their tropism is already known.pt_PT
dc.description.sponsorshipThis work was supported by GenomePT (ref. POCI-01-0145-FEDER-022184) from Fundação para a Ciência e Tecnologia, Portugal and by National Institute of Health Ricardo Jorge, Lisbon, Portugal.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Clin Microbiol Infect Dis. 2020 Dec;39(12):2327-2334. doi: 10.1007/s10096-020-03977-7. Epub 2020 Jul 14.pt_PT
dc.identifier.doi10.1007/s10096-020-03977-7pt_PT
dc.identifier.issn0934-9723
dc.identifier.urihttp://hdl.handle.net/10400.18/7294
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer/ European Society of Microbiologypt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s10096-020-03977-7pt_PT
dc.subjectNeisseria meningitidispt_PT
dc.subjectCapsular Switchingpt_PT
dc.subjectSerogroup Xpt_PT
dc.subjectLung Abscesspt_PT
dc.subjectDoença Meningocócicapt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.titleLung abscess due to Neisseria meningitidis serogroup X-unexpected virulence of a commensal resulting from putative serogroup B capsular switchingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2334pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage2327pt_PT
oaire.citation.titleEuropean Journal of Clinical Microbiology and Infectious Diseases (EJCMID)pt_PT
oaire.citation.volume39pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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