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Nucleoside inhibitors of Zika virus

2016-09-01Journal article Restricted access
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dc.contributor.authorEyer, L.
dc.contributor.authorNencka, R.
dc.contributor.authorHuvarová, I.
dc.contributor.authorPalus, M.
dc.contributor.authorAlves, M.J.
dc.contributor.authorGould, E.A.
dc.contributor.authorDe Clercq, E.
dc.contributor.authorRusek, D.
dc.date.accessioned2017-02-21T11:51:02Z
dc.date.available2017-02-21T11:51:02Z
dc.date.issued2016-09-01
dc.description.abstractThere is growing evidence that Zika virus (ZIKV) can cause devastating infant brain defects and other neurological disorders in humans. However, no specific antiviral therapy is available at present. We tested a series of 2'-C- or 2'-O-methyl-substituted nucleosides, 2'-C-fluoro-2'-C-methyl-substituted nucleosides, 3'-O-methyl-substituted nucleosides, 3'-deoxynucleosides, derivatives with 4'-C-azido substitution, heterobase-modified nucleosides, and neplanocins for their ability to inhibit ZIKV replication in cell culture. Antiviral activity was identified when 2'-C-methylated nucleosides were tested, suggesting that these compounds might represent promising lead candidates for further development of specific antivirals against ZIKV.pt_PT
dc.description.sponsorshipThis work was supported by the Czech Science Foundation (grantGA14–29256S); the Ministry of Education, Youth, and Sports of the Czech Republic, under the NPU I program (grant LO1218); the National Subvention for the Development of Research Organizations (grant RVO:61388963); the European Virus Archive Goes Global project, which has received funding from the European Union’s Horizon 2020 research and innovation program (grant 653316).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Infect Dis. 2016 Sep 1;214(5):707-11. doi: 10.1093/infdis/jiw226. Epub 2016 May 27pt_PT
dc.identifier.doi10.1093/infdis/jiw226pt_PT
dc.identifier.issn0022-1899
dc.identifier.urihttp://hdl.handle.net/10400.18/4303
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Press/Infectious Diseases Society of Americapt_PT
dc.relation.publisherversionhttps://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiw226pt_PT
dc.subjectZika Viruspt_PT
dc.subjectFlaviviruspt_PT
dc.subjectNucleoside Analoguept_PT
dc.subjectAntiviralpt_PT
dc.subjectTherapypt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titleNucleoside inhibitors of Zika viruspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage711pt_PT
oaire.citation.startPage707pt_PT
oaire.citation.titleJournal of Infectious Diseasespt_PT
oaire.citation.volume214(5)pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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