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Publicação
Nucleoside inhibitors of Zika virus
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Orientador(es)
Resumo(s)
There is growing evidence that Zika virus (ZIKV) can cause devastating infant brain defects and other neurological disorders in humans. However, no specific antiviral therapy is available at present. We tested a series of 2'-C- or 2'-O-methyl-substituted nucleosides, 2'-C-fluoro-2'-C-methyl-substituted nucleosides, 3'-O-methyl-substituted nucleosides, 3'-deoxynucleosides, derivatives with 4'-C-azido substitution, heterobase-modified nucleosides, and neplanocins for their ability to inhibit ZIKV replication in cell culture. Antiviral activity was identified when 2'-C-methylated nucleosides were tested, suggesting that these compounds might represent promising lead candidates for further development of specific antivirals against ZIKV.
Descrição
Palavras-chave
Zika Virus Flavivirus Nucleoside Analogue Antiviral Therapy Infecções Sistémicas e Zoonoses
Contexto Educativo
Citação
J Infect Dis. 2016 Sep 1;214(5):707-11. doi: 10.1093/infdis/jiw226. Epub 2016 May 27
Editora
Oxford University Press/Infectious Diseases Society of America