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A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data

2022-08-04Journal article Open access
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dc.contributor.authorTarazona, Jose
dc.contributor.authorCattaneo, Irene
dc.contributor.authorNiemann, Lars
dc.contributor.authorPedraza-Diaz, Susana
dc.contributor.authorGonzález-Caballero, MCarmen
dc.contributor.authorAlba-Gonzalez, Mercedes de
dc.contributor.authorCañas, Ana
dc.contributor.authorDomínguez-Morueco, Noelia
dc.contributor.authorEsteban, Marta
dc.contributor.authorCastano, Argelia
dc.contributor.authorBorges, Teresa
dc.contributor.authorKatsonouri, Andromachi
dc.contributor.authorMakris, Konstantinos C.
dc.contributor.authorOttenbros, Ilse
dc.contributor.authorMol, Hans
dc.contributor.authorDe Decker, Annelies
dc.contributor.authorMorrens, Bert
dc.contributor.authorBerman, Tamar
dc.contributor.authorBarnett-Itzhaki, Zohar
dc.contributor.authorProbst-Hensch, Nicole
dc.contributor.authorFuhrimann, Samuel
dc.contributor.authorSnoj Tratnik, Janja
dc.contributor.authorHorvat, Milena
dc.contributor.authorRAMBAUD, Loic
dc.contributor.authorRIOU, Margaux
dc.contributor.authorSchoeters, Greta
dc.contributor.authorGovarts, Eva
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorWeber, Till
dc.contributor.authorApel, Petra
dc.contributor.authorNamorado, Sónia
dc.contributor.authorSantonen, Tiina
dc.date.accessioned2023-01-10T14:05:34Z
dc.date.available2023-01-10T14:05:34Z
dc.date.issued2022-08-04
dc.descriptionThis article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention?pt_PT
dc.description.abstractPyrethroids are a major insecticide class, suitable for biomonitoring in humans. Due to similarities in structure and metabolic pathways, urinary metabolites are common to various active substances. A tiered approach is proposed for risk assessment. Tier I was a conservative screening for overall pyrethroid exposure, based on phenoxybenzoic acid metabolites. Subsequently, probabilistic approaches and more specific metabolites were used for refining the risk estimates. Exposure was based on 95th percentiles from HBM4EU aligned studies (2014–2021) covering children in Belgium, Cyprus, France, Israel, Slovenia, and The Netherlands and adults in France, Germany, Israel, and Switzerland. In all children populations, the 95th percentiles for 3-phenoxybenzoic acid (3-PBA) exceeded the screening value. The probabilistic refinement quantified the risk level of the most exposed population (Belgium) at 2% or between 1–0.1% depending on the assumptions. In the substance specific assessments, the 95th percentiles of urinary concentrations in the aligned studies were well below the respective human biomonitoring guidance values (HBM-GVs). Both information sets were combined for refining the combined risk. Overall, the HBM data suggest a low health concern, at population level, related to pyrethroid exposure for the populations covered by the studies, even though a potential risk for highly exposed children cannot be completely excluded. The proposed tiered approach, including a screening step and several refinement options, seems to be a promising tool of scientific and regulatory value in future.pt_PT
dc.description.sponsorshipThis study was part of the HBM4EU project receiving funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 733032.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationToxics. 2022 Aug 4;10(8):451. doi: 10.3390/toxics10080451pt_PT
dc.identifier.doi10.3390/toxics10080451pt_PT
dc.identifier.issn2305-6304
dc.identifier.urihttp://hdl.handle.net/10400.18/8412
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.mdpi.com/2305-6304/10/8/451/htmpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectHBM4EUpt_PT
dc.subjectHBM4EU Aligned Studiespt_PT
dc.subjectPyrethroidspt_PT
dc.subjectPesticidespt_PT
dc.subjectBiocidespt_PT
dc.subjectVeterinary Drugspt_PT
dc.subjectRisk assessmentpt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectBiomonitorização Humanapt_PT
dc.subjectPesticidaspt_PT
dc.subjectPiretróidespt_PT
dc.subjectMedicamentos Veterináriospt_PT
dc.subjectBiocidaspt_PT
dc.subjectAvaliação do Riscopt_PT
dc.titleA Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Datapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.issue8pt_PT
oaire.citation.startPage451pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamH2020
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project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
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