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Vitamin D supplementation effects on FoxP3 expression in T cells and FoxP3+/IL-17A ratio and clinical course in systemic lupus erythematosus patients: a study in a Portuguese cohort

2017-02Journal article Restricted access
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dc.contributor.authorMarinho, António
dc.contributor.authorCarvalho, Cláudia
dc.contributor.authorBoleixa, Daniela
dc.contributor.authorBettencourt, Andreia
dc.contributor.authorLeal, Bárbara
dc.contributor.authorGuimarães, Judite
dc.contributor.authorNeves, Esmeralda
dc.contributor.authorOliveira, José Carlos
dc.contributor.authorAlmeida, Isabel
dc.contributor.authorFarinha, Fátima
dc.contributor.authorCosta, Paulo P.
dc.contributor.authorVasconcelos, Carlos
dc.contributor.authorSilva, Berta M.
dc.date.accessioned2018-03-27T14:42:48Z
dc.date.available2018-03-27T14:42:48Z
dc.date.issued2017-02
dc.description.abstractSystemic lupus erythematosus (SLE) is a systemic autoimmune disease with multi-organ inflammation, linked to loss of immune tolerance to self-antigens and the production of a diversity of autoantibodies, with a negative impact on the patients' quality of life. Regulatory T cells have been reported as deficient in number and function in SLE patients. However, some authors also described an enrichment of this cell type. The hypothesis that certain forms of autoimmunity may result from a conversion of Treg cells into a Th17 cell phenotype has been suggested by some studies. In fact, in SLE patients' sera, the IL-17 levels were observed as abnormally high when compared with healthy individuals. Environmental factors, such as vitamin D, that is considered a potential anti-inflammatory agent, combined with genetic and hormonal characteristics have been associated with SLE phenotype and with disease progression. The aim of this study was to evaluate the effect of vitamin D supplementation on FoxP3 expression and IL-17A-producing T cells, through FoxP3+/IL-17A ratio. Additionally, disease evolution, serum vitamin D levels, serum autoantibodies levels and calcium metabolism (to assure safety) were also studied. We assessed 24 phenotypically well-characterized SLE patients. All patients were screened before vitamin D supplementation and 3 and 6 months after the beginning of this treatment. Peripheral blood lymphocyte's subsets were analysed by flow cytometry. Serum 25(OH)D levels significantly increased under vitamin D supplementation (p = 0.001). The FoxP3+/IL-17A ratio in SLE patients after 6 months of vitamin D supplementation was higher than that in the baseline (p < 0.001). In conclusion, this study demonstrated that vitamin D supplementation provided favourable, immunological and clinical impact on SLE.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationImmunol Res. 2017 Feb;65(1):197-206. doi: 10.1007/s12026-016-8829-3pt_PT
dc.identifier.doi10.1007/s12026-016-8829-3pt_PT
dc.identifier.issn0257-277X
dc.identifier.urihttp://hdl.handle.net/10400.18/5476
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHumana Presspt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs12026-016-8829-3pt_PT
dc.subjectAdultpt_PT
dc.subjectAntibodies, Antinuclearpt_PT
dc.subjectCD4-Positive T-Lymphocytespt_PT
dc.subjectCalciumpt_PT
dc.subjectComplement C3pt_PT
dc.subjectFemalept_PT
dc.subjectForkhead Transcription Factorspt_PT
dc.subjectHumanspt_PT
dc.subjectInterleukin-17pt_PT
dc.subjectLupus Erythematosus, Systemicpt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPhosphoruspt_PT
dc.subjectPortugalpt_PT
dc.subjectVitamin Dpt_PT
dc.subjectDietary Supplementspt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleVitamin D supplementation effects on FoxP3 expression in T cells and FoxP3+/IL-17A ratio and clinical course in systemic lupus erythematosus patients: a study in a Portuguese cohortpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage206pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage197pt_PT
oaire.citation.titleImmunologic Researchpt_PT
oaire.citation.volume65pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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