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Activation of RAC1/PAK1 axis potentiates transcriptional upregulation of DNA damage response genes via the BCL6/STAT5 switch

2017-06-01Conference object Restricted access
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dc.contributor.authorBarros, Patrícia
dc.contributor.authorAmaral, Andreia
dc.contributor.authorAbrantes, Leonor
dc.contributor.authorOliveira, Tiago
dc.contributor.authorLourio, Henriqueta
dc.contributor.authorSilva, Maria João
dc.contributor.authorJordan, Peter
dc.contributor.authorGama-Carvalho, Margarida
dc.contributor.authorMatos, Paulo
dc.date.accessioned2018-03-05T18:34:08Z
dc.date.available2018-12-31T01:30:13Z
dc.date.issued2017-06-01
dc.description.abstractColorectal cancer is one of the most prevalent types of cancer worldwide. The GTPase RAC1 and its effector PAK1 have been found overexpressed or hyperactivated in colorectal cancers, particularly those with more aggressive and invasive features, leading to unfavourable clinical prognosis, often resulting from chemoresistance.pt_PT
dc.description.sponsorshipCenter grant UID/MULTI/04046/2013 to BioISI, IF2012 Development grant and PTDC/SAU/GMG/119586/2010 to PM, FCT fellowship SFRH/BPD/94322/2013 to PB and EMBO long-term fellowship ALT-33-2010 and FCT fellowship SFRH/BPD/65976/2009 to AJA.pt_PT
dc.description.versioninfo:eu-repo/semantics/submittedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/5199
dc.language.isoengpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.subjectCancro Coloretalpt_PT
dc.subjectRAC1pt_PT
dc.subjectReparação do DNApt_PT
dc.titleActivation of RAC1/PAK1 axis potentiates transcriptional upregulation of DNA damage response genes via the BCL6/STAT5 switchpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-GMG%2F119586%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F94322%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F65976%2F2009/PT
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.titleSINAL 2017- 8th international meeting on signal transduction, 1-2 junho 2017pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsembargoedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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relation.isProjectOfPublicationd25ce0e4-dab3-4cd3-bf87-0a667e658161
relation.isProjectOfPublication.latestForDiscovery7d792c78-19ac-4b45-9aa2-ce423c26be39

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