Activation of RAC1/PAK1 axis potentiates transcriptional upregulation of DNA damage response genes via the BCL6/STAT5 switch

Barros, Patrícia; Amaral, Andreia; Abrantes, Leonor; Oliveira, Tiago; Lourio, Henriqueta; Silva, Maria João; Jordan, Peter; Gama-Carvalho, Margarida; Matos, Paulo

http://hdl.handle.net/10400.18/5199

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Poster DJI 2017_Patrícia Barros.pdf		1.52 MB	Adobe PDF	Ver/Abrir

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Autores

Gama-Carvalho, Margarida

Matos, Paulo

Resumo(s)

Colorectal cancer is one of the most prevalent types of cancer worldwide. The GTPase RAC1 and its effector PAK1 have been found overexpressed or hyperactivated in colorectal cancers, particularly those with more aggressive and invasive features, leading to unfavourable clinical prognosis, often resulting from chemoresistance.