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Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge

2017-10-10Journal article Open access
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dc.contributor.authorStone, Vicki
dc.contributor.authorMiller, Mark R.
dc.contributor.authorClift, Martin J.D.
dc.contributor.authorElder, Alison
dc.contributor.authorMills, Nicholas L.
dc.contributor.authorMøller, Peter
dc.contributor.authorSchins, Roel P.F.
dc.contributor.authorVogel, Ulla
dc.contributor.authorKreyling, Wolfgang G.
dc.contributor.authorAlstrup Jensen, Keld
dc.contributor.authorKuhlbusch, Thomas A.J.
dc.contributor.authorSchwarze, Per E.
dc.contributor.authorHoet, Peter
dc.contributor.authorPietroiusti, Antonio
dc.contributor.authorDe Vizcaya-Ruiz, Andrea
dc.contributor.authorBaeza-Squiban, Armelle
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorTran, C. Lang
dc.contributor.authorCassee, Flemming R.
dc.date.accessioned2017-10-26T12:37:53Z
dc.date.available2017-10-26T12:37:53Z
dc.date.issued2017-10-10
dc.description.abstractBACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP. METHODS: A workshop of experts systematically analyzed the available information and identified 19 key lessons that can facilitate knowledge exchange between these discipline areas. DISCUSSION: Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment to understanding and defining dose and the molecular mechanisms of toxicity. This review identifies a number of key areas in which additional research prioritization would facilitate both research fields simultaneously. CONCLUSION: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEnviron Health Perspect. 2017 Oct 10;125(10):106002. doi: 10.1289/EHP424pt_PT
dc.identifier.doi10.1289/EHP424pt_PT
dc.identifier.issn0091-6765
dc.identifier.urihttp://hdl.handle.net/10400.18/4798
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNational Institute of Environmental Health Sciences (NIEHS)pt_PT
dc.relation.publisherversionhttps://ehp.niehs.nih.gov/EHP424/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNanomaterialspt_PT
dc.subjectToxicologypt_PT
dc.subjectAmbient Ultrafine Particlespt_PT
dc.subjectHealth Riskpt_PT
dc.subjectReview of Literaturept_PT
dc.titleNanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledgept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue10pt_PT
oaire.citation.startPage106002pt_PT
oaire.citation.titleEnvironmental Health Perspectivespt_PT
oaire.citation.volume125pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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