Ultrastructural and immunofluorescence studies of Zika infection

Alves de Matos, A.P.; Zé-Zé, Líbia; Amaro, Fátima; Alves, Maria João

http://hdl.handle.net/10400.18/5470

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Abstract(s)

Zika virus is a flavivirus transmitted by mosquitoes from the Aedes genus, sexually, or by vertical transmission. It was discovered in 1947 in Africa and it is thought to produce, in some cases, microcephaly in newborns and the Guilan–Barre syndrome in adults. The otherwise low pathogenicity of the virus for humans precluded its detailed study. Recently, outbreaks in Pacific islands, with a virus related to Asian strains, were followed by a large outbreak in Brazil, which easily spread to all Latin-American countries and Cape Verde in África. Ultrastructural information on Zika’s effects on cells is very limited. Also an early histopathological study signaled alterations on other organs, which have not been further explored. (...)