Publicação
SCCS opinion on biphenyl-2-ol and sodium 2-biphenylolate used in cosmetic products (CAS/EC No. 90–43–7/201–993–5 and 132–27–4/205–055–6)– SCCS/1669/24
| dc.contributor.author | European Commission. Scientific Committee on Consumer Safety | |
| dc.date.accessioned | 2026-02-09T15:55:51Z | |
| dc.date.available | 2026-02-09T15:55:51Z | |
| dc.date.issued | 2025-04-01 | |
| dc.description | SCCS External :experts: E. Benfentati (Rapporteur), N. Cabaton, E. Corsini, Ch. Delmaar, A. Koutsodimou, H. Louro , W. Uter, N. von Goetz | |
| dc.description | Adopted on: 27 March 2025 | |
| dc.description.abstract | The SCCS concludes the following: 1. In light of the data provided and taking under consideration the concerns related to potential endocrine disrupting properties of Benzophenone-1, does the SCCS consider Benzophenone-1 safe when used as a light stabilizer in cosmetic products up to a maximum concentration of 2%? Having considered the data provided (including two new mutagenicity/genotoxicity studies submitted to ECHA as part of the REACH registration dossier), and the concerns relating to genotoxicity and potential endocrine disrupting properties, the SCCS considers Benzophenone-1 not safe when used as a light stabiliser in cosmetic products for the following reasons: • The available data indicate genotoxicity potential of Benzophenone-1. • The evidence assessed by the SCCS also shows that Benzophenone-1 is an endocrine-active substance due to clear demonstration of estrogenic activity and weak anti-androgenic activity both in vitro and in vivo, and potential activity against thyroid modality in vitro. A new (2023) OECD TG 422 study relating to ED effects submitted to ECHA as part of the REACH registration dossier has not been assessed by the SCCS at this stage because of the remaining concerns over genotoxicity of Benzophenone-1. The SCCS will be ready to assess the evidence in support of the safe use of Benzophenone-1 in cosmetic products when received in a new mandate. 2. Alternatively, what is according to the SCCS the maximum concentration considered safe for use of Benzophenone-1 in cosmetic products? / 3. Does the SCCS have any further scientific concerns with regard to the use of Benzophenone-1 in cosmetic products? The SCCS mandate does not address environmental aspects. Therefore, this assessment has not covered the safety of BP-1 for the environment. | eng |
| dc.identifier.issn | 3050-6204 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/10871 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | European Commission | |
| dc.relation.hasversion | https://health.ec.europa.eu/publications/sccs-opinion-benzophenone-1-cas-no-131-56-6-ec-no-205-029-4_en#details | |
| dc.relation.ispartof | NAM Journal | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Benzophenone-1 | |
| dc.subject | Cosmetic Ingredients | |
| dc.subject | Safety Assessment | |
| dc.subject | Environmental Genotoxicity | |
| dc.subject | CAS No. 131-56-6 | |
| dc.subject | EC No. 205-029-4 | |
| dc.subject | SCCS | |
| dc.subject | Genotoxicidade Ambiental | |
| dc.title | SCCS opinion on biphenyl-2-ol and sodium 2-biphenylolate used in cosmetic products (CAS/EC No. 90–43–7/201–993–5 and 132–27–4/205–055–6)– SCCS/1669/24 | eng |
| dc.type | report | |
| dspace.entity.type | Publication | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |