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Predominance of KPC-3 in a Survey for Carbapenemase-Producing Enterobacteriaceae in Portugal

2015Journal article Open access
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dc.contributor.authorManageiro, Vera
dc.contributor.authorFerreira, Eugénia
dc.contributor.authorAlmeida, Joana
dc.contributor.authorBarbosa, Stephanie
dc.contributor.authorSimões, Constança
dc.contributor.authorBonomo, Robert A.
dc.contributor.authorCaniça, Manuela
dc.date.accessioned2016-03-22T17:18:08Z
dc.date.available2016-03-22T17:18:08Z
dc.date.issued2015
dc.descriptionFree PMC Article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432220/pt_PT
dc.description.abstractAmong the 2,105 Enterobacteriaceae tested in a survey done in Portugal, 165 were nonsusceptible to carbapenems, from which 35 (26 Klebsiella pneumoniae, 3 Escherichia coli, 2 Enterobacter aerogenes, and 3 Enterobacter cloacae isolates and 1 Klebsiella oxytoca isolate) were confirmed to be carbapenemase producers by the presence of 30 Tn4401d-blaKPC-3, 4 intI3-blaGES-5, and one intI1-blaVIM-2 gene, alone or in combination with other bla genes. The dissemination of blaKPC-3 gene carried by an IncF plasmid suggests lateral gene transfer as a major mechanism of dissemination.pt_PT
dc.description.sponsorshipV. Manageiro was supported by grant SFRH/BPD/77486/2011 from the Fundação para a Ciência e a Tecnologia, Lisbon, Portugal. J. Almeida was supported by grant BRJ-SUB/01/2012 from the National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal. R. A. Bonomo was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under awards R01 AI100560 and R01 AI063517, and by the Cleveland Department of Veterans Affairs, the Veterans Affairs Merit Review Program, and the Geriatric Research Education and Clinical Center VISN 10. We thank the Fundação para a Ciência e a Tecnologia (FCT) for project grant PEst-OE/AGR/UI0211/2011-2014, Strategic Project UI211- 2011-2014.pt_PT
dc.identifier.citationAntimicrob Agents Chemother. 2015;59(6):3588-92. doi: 10.1128/AAC.05065-14. Epub 2015 Mar 16.pt_PT
dc.identifier.doi10.1128/AAC.05065-14pt_PT
dc.identifier.issn0066-4804
dc.identifier.urihttp://hdl.handle.net/10400.18/3720
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Society for Microbiologypt_PT
dc.relation.publisherversionhttp://aac.asm.org/content/59/6/3588.longpt_PT
dc.subjectResistência aos Antibióticospt_PT
dc.subjectCarbapenemasespt_PT
dc.subjectKPC-3pt_PT
dc.subjectPortugalpt_PT
dc.subjectEnterobacteriaceaept_PT
dc.titlePredominance of KPC-3 in a Survey for Carbapenemase-Producing Enterobacteriaceae in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0211%2F2014/PT
oaire.citation.endPage3592pt_PT
oaire.citation.startPage3588pt_PT
oaire.citation.titleAntimicrobial Agents and Chemotherapypt_PT
oaire.citation.volume59(8)pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationd3e4188b-642e-4ad7-9a4d-aeea65a89449
relation.isProjectOfPublication.latestForDiscoveryd3e4188b-642e-4ad7-9a4d-aeea65a89449

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