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rTgOWP1-f, a specific biomarker for Toxoplasma gondii oocysts

2020-05-14Journal article Unknown
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dc.contributor.authorSousa, Susana
dc.contributor.authorAlmeida, André
dc.contributor.authorDelgado, Lurdes
dc.contributor.authorConceição, Antónia
dc.contributor.authorMarques, Cláudia
dc.contributor.authorda Costa, José Manuel Correia
dc.contributor.authorCastro, António
dc.date.accessioned2021-04-01T14:39:28Z
dc.date.available2021-04-01T14:39:28Z
dc.date.issued2020-05-14
dc.description.abstractToxoplasma gondii oocyst wall protein 1 (TgOWP1) integrates a family of seven proteins, consensually assumed as specific antigens of Toxoplasma gondii oocyst stage, located in the outer layer of the oocyst wall. Herein, we notice the expression of a recombinant antigen, rTgOWP1-f, derived from a fragment selected on basis of its structural homology with Plasmodium MSP1-19. Rabbit polyclonal antibodies anti-rTgOWP1-f evidence ability for specific identification of environmental T. gondii oocysts. We assume, rTgOWP1-f, as a possible biomarker of oocysts. In addition, we present findings supporting this vision, including the development of an immunodetection method for T. gondii oocysts identification.pt_PT
dc.description.sponsorshipThis research was supported by the Horizon 2020 project SafeConsume (Grant Agreement No. 727580), and FCT funding UIDB/00211/2020.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSci Rep. 2020 May 14;10(1):7947. doi: 10.1038/s41598-020-64590-4pt_PT
dc.identifier.doi10.1038/s41598-020-64590-4pt_PT
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.18/7624
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Researchpt_PT
dc.relationSafeConsumE: Safer food through changed consumer behavior: Effective tools and products, communication strategies, education and a food safety policy reducing health burden from foodborne illnesses
dc.relationCenter for the Study of Animal Science
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-020-64590-4pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAmino Acid Sequencept_PT
dc.subjectBiomarkerspt_PT
dc.subjectModels, Molecularpt_PT
dc.subjectOocystspt_PT
dc.subjectProtein Conformationpt_PT
dc.subjectProtozoan Proteinspt_PT
dc.subjectToxoplasmapt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titlerTgOWP1-f, a specific biomarker for Toxoplasma gondii oocystspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSafeConsumE: Safer food through changed consumer behavior: Effective tools and products, communication strategies, education and a food safety policy reducing health burden from foodborne illnesses
oaire.awardTitleCenter for the Study of Animal Science
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/727580/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00211%2F2020/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage7947pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com página web do editor da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationb5725ac7-5357-4923-84c6-f0a9e73ea1fb
relation.isProjectOfPublication69b75eb9-6f25-4ad8-98db-6cc7e9bcdcc7
relation.isProjectOfPublication.latestForDiscoveryb5725ac7-5357-4923-84c6-f0a9e73ea1fb

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