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The role of estrogens and estrogen receptor signaling pathways in cancer and infertility: the case of schistosomes

2015-06Journal article Open access
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dc.contributor.authorBotelho, M.C.
dc.contributor.authorAlves, H.
dc.contributor.authorBarros, A.M.
dc.contributor.authorRinaldi, G.
dc.contributor.authorBrindley, P.J.
dc.contributor.authorSousa, M.
dc.date.accessioned2016-02-17T17:45:04Z
dc.date.available2016-12-01T01:30:07Z
dc.date.issued2015-06
dc.description.abstractSchistosoma haematobium, a parasitic flatworm that infects more than 100 million people, mostly in the developing world, is the causative agent of urogenital schistosomiasis, and is associated with a high incidence of squamous cell carcinoma (SCC) of the bladder. Schistosomiasis haematobia also appears to negatively influence fertility, and is particularly associated with female infertility. Given that estrogens and estrogen receptors are key players in human reproduction, we speculate that schistosome estrogen-like molecules may contribute to infertility through hormonal imbalances. Here, we review recent findings on the role of estrogens and estrogen receptors on both carcinogenesis and infertility associated with urogenital schistosomiasis and discuss the basic hormonal mechanisms that might be common in cancer and infertility.pt_PT
dc.identifier.citationTrends Parasitol. 2015 Jun;31(6):246-250. doi: 10.1016/j.pt.2015.03.005. Epub 2015 Mar 30.pt_PT
dc.identifier.doi10.1016/j.pt.2015.03.005pt_PT
dc.identifier.issn1471-4922
dc.identifier.urihttp://hdl.handle.net/10400.18/3391
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S147149221500046Xpt_PT
dc.subjectSchistosomiasispt_PT
dc.subjectEstrogen Receptorpt_PT
dc.subjectCancerpt_PT
dc.subjectInfertilitypt_PT
dc.titleThe role of estrogens and estrogen receptor signaling pathways in cancer and infertility: the case of schistosomespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage250pt_PT
oaire.citation.startPage246pt_PT
oaire.citation.titleTrends in Parasitologypt_PT
oaire.citation.volume31(6)pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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