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Relevance of physicochemical characterization in nanotoxicology studies

2016-04-08Lecture Restricted access
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dc.contributor.authorLouro, Henriqueta
dc.contributor.authorTavares, Ana
dc.contributor.authorPinhão, Mariana
dc.contributor.authorSantos, Joana
dc.contributor.authorSilva, M.J.
dc.date.accessioned2016-05-24T16:15:42Z
dc.date.available2016-05-24T16:15:42Z
dc.date.issued2016-04-08
dc.description.abstractNanomaterials (NMs) with the same chemistry can greatly differ by size, surface area, shape, stability, rigidness, coating or electrical charge and these characteristics affect nano-bio interactions, leading to different toxic potential. In this communication is shown that closely related NMs can have different genotoxic effects, evidencing the importance of investigating the toxic potential of each NM individually, instead of assuming a common mechanism and equal genotoxic effects for a set of similar NMs. The importance of considering complexity of in vivo systems in nanotoxicology, such as the use of tridimensional cellular models, air-liquid interface exposure or in vivo models that mimic human routes of exposure, is underlined.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/3816
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.publisherInstituto Nacional de Saúde Doutor Ricardo Jorge, IPpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectNanomaterialspt_PT
dc.subjectPhysicochemichal Characterizationpt_PT
dc.titleRelevance of physicochemical characterization in nanotoxicology studiespt_PT
dc.typelecture
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.titleWorkshop Trends in Nanobioparticles Characterization, National Institute of Health Dr Ricardo Jorge, 6-8 April 2016pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typelecturept_PT

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