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Evaluation of ECDC Influenza-like illness (ILI) case definition to detect respiratory syncytial virus (RSV) infection through the Influenza Surveillance System in Portugal, 2010-2018

2018-11-21Conference object Open access
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dc.contributor.authorSáez-Lopes, Emma
dc.contributor.authorPechirra, Pedro
dc.contributor.authorCosta, Inês
dc.contributor.authorCristóvão, Paula
dc.contributor.authorMachado, Ausenda
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorGuiomar, Raquel
dc.date.accessioned2019-02-15T16:01:07Z
dc.date.available2019-02-15T16:01:07Z
dc.date.issued2018-11-21
dc.descriptionINSA-DDI em colaboração com Emma Sáez-López (programa EUPHEM) e INSA-DEP.pt_PT
dc.descriptionPoster abstract publicado em: ESCAIDE 2018: Abstract book, pp. 87-88. Disponível em: https://www.escaide.eu/sites/escaide/files/documents/book_escaide2018_updated-dec-2018.pdf
dc.description.abstractBackground: One of the main problems to implement a global Respiratory syncytial virus (RSV) surveillance system is the lack of a suitable case definition for RSV disease. In Portugal, RSV cases are detected through the Influenza Surveillance System (ISS) using the ECDC Influenza-like illness (ILI) case definition. The aim of this study was to evaluate the suitability of this case definition to detect RSV infections in Portugal. Methods: We conducted a retrospective and observational cross-sectional study of 4,711 cases with individual clinical symptoms and laboratory-confirmed result for respiratory virus between October 2010 and May 2017. Association between clinical characteristics and RSV detection using bivariate and multinomial logistic regression was carried out. The ILI case definition accuracy was assessed by its sensitivity, specificity, and area under the receiver operating characteristic curve (AUC). A 0.05 significance level was accepted. Results: A total of 141 (3%) samples were laboratory-confirmed RSV positive cases, being highly significant among children less than 5 years old (8.5%) and among adults ≥ 65 years old (23%). Cough (OR=2.71; 95CI 1.19-6.18) and difficulty breathing (OR=2.16; 95CI 1.53-3.06) were the best predictors for RSV infections. However, fever or feverishness (OR=0.4; 95CI 0.27-0.59), headache (OR=0.65; 95CI0.46-0.93) and myalgia (OR=0.34; 95CI 0.23-0.5) were negative associated with RSV disease although were significantly associated with influenza positive cases. The ILI case definition was not significant and showed a sensitivity of 80.9% (73.4-87), specificity of 19.7% (18.6-20.9) and an AUC of 0.623. Conclusions: We showed that ILI case definition was not accurate for RSV detection in Portugal. Therefore, the case definition should be adapted within the ISS or a specific RSV surveillance system should be implemented in Portugal.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/5837
dc.language.isoengpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectRSVpt_PT
dc.subjectInfluenza Surveillancept_PT
dc.subjectILIpt_PT
dc.subjectSurveillancept_PT
dc.subjectRespiratory Syncytial Viruspt_PT
dc.subjectInfluenza-like illnesspt_PT
dc.subjectCase Definitionpt_PT
dc.subjectSurveillancept_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.titleEvaluation of ECDC Influenza-like illness (ILI) case definition to detect respiratory syncytial virus (RSV) infection through the Influenza Surveillance System in Portugal, 2010-2018pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceSaint Julian’s, Maltapt_PT
oaire.citation.titleESCAIDE 2018 - European Scientific Conference on Applied Infectious Disease Epidemiology, 21-23 November 2018pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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