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Browsing by Issue Date, starting with "2018-11-21"

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  • Evaluation of ECDC Influenza-like illness (ILI) case definition to detect respiratory syncytial virus (RSV) infection through the Influenza Surveillance System in Portugal, 2010-2018
    Publication . Sáez-Lopes, Emma; Pechirra, Pedro; Costa, Inês; Cristóvão, Paula; Machado, Ausenda; Rodrigues, Ana Paula; Guiomar, Raquel
    Background: One of the main problems to implement a global Respiratory syncytial virus (RSV) surveillance system is the lack of a suitable case definition for RSV disease. In Portugal, RSV cases are detected through the Influenza Surveillance System (ISS) using the ECDC Influenza-like illness (ILI) case definition. The aim of this study was to evaluate the suitability of this case definition to detect RSV infections in Portugal. Methods: We conducted a retrospective and observational cross-sectional study of 4,711 cases with individual clinical symptoms and laboratory-confirmed result for respiratory virus between October 2010 and May 2017. Association between clinical characteristics and RSV detection using bivariate and multinomial logistic regression was carried out. The ILI case definition accuracy was assessed by its sensitivity, specificity, and area under the receiver operating characteristic curve (AUC). A 0.05 significance level was accepted. Results: A total of 141 (3%) samples were laboratory-confirmed RSV positive cases, being highly significant among children less than 5 years old (8.5%) and among adults ≥ 65 years old (23%). Cough (OR=2.71; 95CI 1.19-6.18) and difficulty breathing (OR=2.16; 95CI 1.53-3.06) were the best predictors for RSV infections. However, fever or feverishness (OR=0.4; 95CI 0.27-0.59), headache (OR=0.65; 95CI0.46-0.93) and myalgia (OR=0.34; 95CI 0.23-0.5) were negative associated with RSV disease although were significantly associated with influenza positive cases. The ILI case definition was not significant and showed a sensitivity of 80.9% (73.4-87), specificity of 19.7% (18.6-20.9) and an AUC of 0.623. Conclusions: We showed that ILI case definition was not accurate for RSV detection in Portugal. Therefore, the case definition should be adapted within the ISS or a specific RSV surveillance system should be implemented in Portugal.
    2018-11-21Conference object Open access Show more
  • Performance of ECDC ILI case definition and ICPC R80 code for influenza surveillance
    Publication . Pinto Leite, Pedro; Rodrigues, Ana Paula; Guiomar, Raquel
    In this study we took advantage of the Portuguese Influenza Surveillance Systems (ISS) database to assess and compare the performance of the two main case definitions used in Portugal: the European Centre for Disease Prevention and Control (ECDC) ILI case definition and the International Classification of Primary Care (ICPC) R80 code.
    2018-11-21Conference object Open access Show more
  • Rede Nacional para Vigilância Laboratorial de Infeções Fúngicas Invasivas e Subcutâneas: ponto da situação
    Publication . Verissimo, Cristina
    A apresentação enquadra-se na II Reunião da Rede Nacional para Vigilância Laboratorial das Infeções Fúngicas Invasivas e Subcutâneas e foca os resultados obtidos por esta rede no período 2013-2018
    2018-11-21Conference object Unknown Show more
  • Diagnóstico molecular das infeções fúngicas: o que há de novo
    Publication . Sabino, Raquel
    A apresentação enquadra-se na II Reunião da Rede Nacional para Vigilância Laboratorial das Infeções Fúngicas Invasivas e Subcutâneas e foca as novas metodologias moleculares disponíveis para o diagnóstico das infeções fúngicas invasivas e subcutâneas.
    2018-11-21Conference object Unknown Show more