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Methylmercury: A Human Biomonitoring Study of Portuguese Women of Childbearing Age

2021-08-25Documento de conferência Acesso restrito
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dc.contributor.authorSantiago, Susana
dc.contributor.authorNamorado, Sónia
dc.contributor.authorMatias Dias, Carlos
dc.contributor.authorMartins, Carla
dc.contributor.authorCarvalho, Cristina
dc.contributor.authorAssunção, Ricardo
dc.date.accessioned2022-07-08T15:58:12Z
dc.date.available2022-07-08T15:58:12Z
dc.date.issued2021-08-25
dc.descriptionAbstract publicado em: Environ Health Perspect. 2021;1. https://ehp.niehs.nih.gov/doi/abs/10.1289/isee.2021.P-457pt_PT
dc.description.abstractBACKGROUND AND AIM: Methylmercury (MeHg) is a toxic compound that undergoes bioaccumulation in the aquatic food chain. Predatory fish species are an important human exposure source. Portugal has the highest consumption of fishery products in the European Union (EU), above the EU and world average. The main target of MeHg is the central nervous system and the prenatal period represents a period of greatest vulnerability regarding neurodevelopmental effects on the foetus. Human biomonitoring (HBM) allows direct exposure assessment of human exposure to chemical compounds. Total mercury (THg) concentration in blood is usually considered an appropriate biomarker for estimating short-term internal exposure to MeHg in individuals with regular fish consumption. The aim of the present study was to evaluate the exposure of Portuguese women of childbearing age to MeHg through HBM. METHODS: Three hundred Portuguese women of childbearing age (25 to 44 years) were randomly selected among the participants in a cross-sectional epidemiological study carried out in Portugal (INSEF) in 2015. THg content was determined in whole blood samples by thermal decomposition and amalgamation atomic absorption spectrophotometry (TDA/AAS). RESULTS:Two samples had THg levels below LOQ (0.5 µg/L), and in the remaining (n=298), THg levels ranged from 0.6 to 35.0 µg/L. About 52% of the samples had values below 5 µg/L, a HBM value below which no adverse health effects are expected. However, 48% of samples revealed levels above 5 µg/L and therefore presented risk of adverse health effects. Blood mercury concentration values were higher in older women, in higher education level and residents in the Autonomous Region of Madeira, with statistically significant differences compared to the other groups (p<0.05). CONCLUSIONS:This study reinforces the need to develop and implement in Portugal strategies regarding risk communication focused on the selection of fish species with lower MeHg concentration in order to reduce human exposure to this compound.pt_PT
dc.description.sponsorshipThis work was funded by FCT/MCTES through national funds to CESAM (UIDP/50017/2020+UIDB/50017/2020).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/8106
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectSaúde Ambientalpt_PT
dc.subjectBiomonitorização Humanapt_PT
dc.subjectExposição a Químicospt_PT
dc.subjectBiomarcadores de Exposiçãopt_PT
dc.subjectAvaliação da Exposiçãopt_PT
dc.subjectMercúriopt_PT
dc.subjectMulheres em Idade Fértilpt_PT
dc.subjectPortugalpt_PT
dc.subjectINSEF 2015pt_PT
dc.subjectMethylmercurypt_PT
dc.titleMethylmercury: A Human Biomonitoring Study of Portuguese Women of Childbearing Agept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.citation.conferencePlace(Online)pt_PT
oaire.citation.title33rd Annual Conference of the International Society for Environmental Epidemiology (ISEE 2021) "Promoting Environmental Health and Equity in a Shifting Climate", 23-26 August 2021pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameNamorado
person.familyNameMatias Dias
person.givenNameSónia
person.givenNameCarlos
person.identifier.ciencia-id6311-6117-ADEB
person.identifier.orcid0000-0002-7500-8811
person.identifier.orcid0000-0002-0206-5874
person.identifier.ridD-7168-2015
person.identifier.ridI-6335-2012
person.identifier.scopus-author-id14047182500
person.identifier.scopus-author-id23103292400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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