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Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities

2021-04Journal article Open access
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dc.contributor.authorChen, Kai
dc.contributor.authorBreitner, Susanne
dc.contributor.authorWolf, Kathrin
dc.contributor.authorStafoggia, Massimo
dc.contributor.authorSera, Francesco
dc.contributor.authorVicedo-Cabrera, Ana M.
dc.contributor.authorGuo, Yuming
dc.contributor.authorTong, Shilu
dc.contributor.authorLavigne, Eric
dc.contributor.authorMatus, Patricia
dc.contributor.authorValdés, Nicolás
dc.contributor.authorKan, Haidong
dc.contributor.authorJaakkola, Jouni J.K.
dc.contributor.authorRyti, Niilo R.I.
dc.contributor.authorHuber, Veronika
dc.contributor.authorScortichini, Matteo
dc.contributor.authorHashizume, Masahiro
dc.contributor.authorHonda, Yasushi
dc.contributor.authorNunes, Baltazar
dc.contributor.authorMadureira, Joana
dc.contributor.authorHolobâcă, Iulian Horia
dc.contributor.authorFratianni, Simona
dc.contributor.authorKim, Ho
dc.contributor.authorLee, Whanhee
dc.contributor.authorTobias, Aurelio
dc.contributor.authorÍñiguez, Carmen
dc.contributor.authorForsberg, Bertil
dc.contributor.authorÅström, Christofer
dc.contributor.authorRagettli, Martina S-
dc.contributor.authorGuo, Yue-Liang Leon
dc.contributor.authorChen, Bing-Yu
dc.contributor.authorLi, Shanshan
dc.contributor.authorMilojevic, Ai
dc.contributor.authorZanobetti, Antonella
dc.contributor.authorSchwartz, Joel
dc.contributor.authorBell, Michelle L-
dc.contributor.authorGasparrini, Antonio
dc.contributor.authorSchneider, Alexandra
dc.date.accessioned2022-07-06T16:06:07Z
dc.date.available2022-07-06T16:06:07Z
dc.date.issued2021-04
dc.description.abstractBackground: Epidemiological evidence on short-term association between ambient carbon monoxide (CO) and mortality is inconclusive and limited to single cities, regions, or countries. Generalisation of results from previous studies is hindered by potential publication bias and different modelling approaches. We therefore assessed the association between short-term exposure to ambient CO and daily mortality in a multicity, multicountry setting. Methods: We collected daily data on air pollution, meteorology, and total mortality from 337 cities in 18 countries or regions, covering various periods from 1979 to 2016. All included cities had at least 2 years of both CO and mortality data. We estimated city-specific associations using confounder-adjusted generalised additive models with a quasi-Poisson distribution, and then pooled the estimates, accounting for their statistical uncertainty, using a random-effects multilevel meta-analytical model. We also assessed the overall shape of the exposure-response curve and evaluated the possibility of a threshold below which health is not affected. Findings: Overall, a 1 mg/m3 increase in the average CO concentration of the previous day was associated with a 0·91% (95% CI 0·32-1·50) increase in daily total mortality. The pooled exposure-response curve showed a continuously elevated mortality risk with increasing CO concentrations, suggesting no threshold. The exposure-response curve was steeper at daily CO levels lower than 1 mg/m3, indicating greater risk of mortality per increment in CO exposure, and persisted at daily concentrations as low as 0·6 mg/m3 or less. The association remained similar after adjustment for ozone but was attenuated after adjustment for particulate matter or sulphur dioxide, or even reduced to null after adjustment for nitrogen dioxide. Interpretation: This international study is by far the largest epidemiological investigation on short-term CO-related mortality. We found significant associations between ambient CO and daily mortality, even at levels well below current air quality guidelines. Further studies are warranted to disentangle its independent effect from other traffic-related pollutants.pt_PT
dc.description.sponsorshipThis study was supported by the European Union’s Horizon 2020 Project Exhaustion (grant ID 820655), UK Medical Research Council (MR/R013349/1), and UK Natural Environment Research Council (NE/R009384/1). JM was supported by the Fundação para a Ciência e a Tecnologia through the scholarship SFRH/BPD/115112/2016. VH received funding from the Spanish Ministry of Economy, Industry and Competitiveness (PCIN-2017-046), and the German Federal Ministry of Education and Research (01LS1201A2). YG was supported by a Career Development Fellowship of the Australian National Health and Medical Research Council (APP1163693). SL was supported by an Early Career Fellowship of the Australian National Health and Medical Research Council (APP1109193). ST was supported by the Shanghai Municipal Science and Technology Commission (grant 18411951600).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLancet Planet Health. 2021 Apr;5(4):e191-e199. doi: 10.1016/S2542-5196(21)00026-7pt_PT
dc.identifier.doi10.1016/S2542-5196(21)00026-7pt_PT
dc.identifier.issn2542-5196
dc.identifier.urihttp://hdl.handle.net/10400.18/8075
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationExposure to heat and air pollution in EUrope – cardiopulmonary impacts and benefits of mitigation and adaptation
dc.relationEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
dc.relation.publisherversionhttps://www.thelancet.com/journals/lanplh/article/PIIS2542-5196(21)00026-7/fulltextpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMCCpt_PT
dc.subjectAmbient Carbon Monoxidept_PT
dc.subjectDaily Mortalitypt_PT
dc.subjectTime Seriespt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleAmbient carbon monoxide and daily mortality: a global time-series study in 337 citiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleExposure to heat and air pollution in EUrope – cardiopulmonary impacts and benefits of mitigation and adaptation
oaire.awardTitleEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/820655/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F115112%2F2016/PT
oaire.citation.endPagee199pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPagee191pt_PT
oaire.citation.titleThe Lancet Planetary Healthpt_PT
oaire.citation.volume5pt_PT
oaire.fundingStreamH2020
person.familyNameNunes
person.givenNameBaltazar
person.identifier.ciencia-idAB11-AD48-A8DF
person.identifier.orcid0000-0001-6230-7209
person.identifier.scopus-author-id9133723200
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com página web do editor da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isProjectOfPublication59609b8b-2750-43e0-8fe9-155a4915a572
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