Genotoxic effect of transplacental exposure to tobacco smoke

Alves, A.C.; Costa, C.; Tirsina, A.; Monteiro, M.S.; Soares, A.M.; Loureiro, S.; Teixeira, J.P.

http://hdl.handle.net/10400.18/4588

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Abstract(s)

The effect of transplacental exposure to environmental pollutants in birth outcomes has been a matter of interest to the scientific community for several years. In the past, some studies have been carried out assessing biomarkers of early effect, such as DNA adducts, micronuclei, DNA damage and more recently, epigenetic alterations. Herein, the main goal was to analyse the possible effect of mother tobacco smoke status in the levels of DNA damage evaluated in cord blood samples using the alkaline comet assay.