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The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review

2022-08-17Journal article Open access
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dc.contributor.authorLouro, Henriqueta
dc.contributor.authorGomes, Bruno Costa
dc.contributor.authorSaber, Anne Thoustrup
dc.contributor.authorIamiceli, Anna Laura
dc.contributor.authorGöen, Thomas
dc.contributor.authorJones, Kate
dc.contributor.authorKatsonouri, Andromachi
dc.contributor.authorNeophytou, Christiana M.
dc.contributor.authorVogel, Ulla
dc.contributor.authorVentura, Célia
dc.contributor.authorOberemm, Axel
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorFernandez, Mariana F.
dc.contributor.authorOlea, Nicolas
dc.contributor.authorSantonen, Tiina
dc.contributor.authorViegas, Susana
dc.contributor.authorSilva, Maria João
dc.date.accessioned2022-11-02T14:43:36Z
dc.date.available2022-11-02T14:43:36Z
dc.date.issued2022-08-17
dc.descriptionReviewpt_PT
dc.descriptionThis article belongs to the Special Issue Biomonitoring of Human Exposure: From Individual to Group Exposure Assessmentpt_PT
dc.description.abstractPolycyclic aromatic hydrocarbons (PAHs) are among the chemicals with proven impact on workers’ health. The use of human biomonitoring (HBM) to assess occupational exposure to PAHs has become more common in recent years, but the data generated need an overall view to make them more usable by regulators and policymakers. This comprehensive review, developed under the Human Biomonitoring for Europe (HBM4EU) Initiative, was based on the literature available from 2008–2022, aiming to present and discuss the information on occupational exposure to PAHs, in order to identify the strengths and limitations of exposure and effect biomarkers and the knowledge needs for regulation in the workplace. The most frequently used exposure biomarker is urinary 1-hydroxypyrene (1-OH-PYR), a metabolite of pyrene. As effect biomarkers, those based on the measurement of oxidative stress (urinary 8-oxo-dG adducts) and genotoxicity (blood DNA strand-breaks) are the most common. Overall, a need to advance new harmonized approaches both in data and sample collection and in the use of appropriate biomarkers in occupational studies to obtain reliable and comparable data on PAH exposure in different industrial sectors, was noted. Moreover, the use of effect biomarkers can assist to identify work environments or activities of high risk, thus enabling preventive risk mitigation and management measures.pt_PT
dc.description.sponsorshipThis project has received funding from the European Unions’ Horizon 2020 research and innovation Programme under grant agreement No 733032. HBM4EU.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationToxics. 2022 Aug 17;10(8):480. doi: 10.3390/toxics10080480pt_PT
dc.identifier.doi10.3390/toxics10080480pt_PT
dc.identifier.issn2305-6304
dc.identifier.urihttp://hdl.handle.net/10400.18/8298
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.mdpi.com/2305-6304/10/8/480pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPolycyclic Aromatic Hydrocarbonspt_PT
dc.subjectPAHspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectOccupational Exposurept_PT
dc.subjectExposure Biomarkerpt_PT
dc.subjectEffect Biomarkerpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectEuropept_PT
dc.titleThe Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.issue8pt_PT
oaire.citation.startPage480pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamH2020
person.familyNameLouro
person.familyNameVentura
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameCélia
person.givenNameMaria Joao
person.identifier157627
person.identifier2056460
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id6116-89BA-C617
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-0637-2222
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationfa89f42b-12a4-47bd-a4fb-0f65cbc06885
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscoveryfa89f42b-12a4-47bd-a4fb-0f65cbc06885
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
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