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New insights into how cancer cells regulate glucose uptake by protein phosphorylation

2018-10Conference object Restricted access
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dc.contributor.authorHenriques, Andreia
dc.contributor.authorMatos, Paulo
dc.contributor.authorClarke, Luka
dc.contributor.authorJordan, Peter
dc.date.accessioned2019-02-14T11:19:54Z
dc.date.available2020-06-01T00:30:16Z
dc.date.issued2018-10
dc.description.abstractCancer cells require increased amounts of glucose to sustain their proliferation and upregulate plasma membrane expression of glucose transporter GLUT1. In insulin responsive cells, glucose uptake requires previous phosphorylation of TBC1D4, a negative regulator of endosomal GLUT traffic. Previous work published by the host lab has discovered that protein kinase WNK1 can also phosphorylate TBC1D4 and promote the translocation of GLUT1 to the cell surface. In vitro, WNK1 also phosphorylates the homologue TBC1D1 for which a role in cancer cell glucose uptake is not known.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/5816
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectCancerpt_PT
dc.subjectCancer Cellspt_PT
dc.subjectWNK Portien Kinasept_PT
dc.subjectGlucosept_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.titleNew insights into how cancer cells regulate glucose uptake by protein phosphorylationpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceBilbao, Espanhapt_PT
oaire.citation.titleMechanisms to Therapies: Innovations in Cancer Metabolism Bilbao, 9-11 October 2018pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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