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Advisor(s)
Abstract(s)
O número de infeções fúngicas nosocomiais tem vindo
a aumentar drasticamente sendo causa, cada vez mais
comum, de elevada morbilidade e mortalidade em doentes
hospitalizados. O grau de contaminação fúngica ambiental é
considerado um fator de extrema importância na incidência
e epidemiologia destas infeções. Em contexto hospitalar,
a infeção fúngica poderá ocorrer por contacto direto ou
indireto com superfícies ou objetos contaminados, através
das mãos de profissionais de saúde e por ingestão ou
inalação de partículas ou bioaerossóis contaminados. As
espécies de Aspergillus e Candida são responsáveis pela
maioria das infeções fúngicas em pacientes imunocomprometidos
e são frequentemente isolados em ambiente
hospitalar. Descrevem-se neste trabalho dois case-study em
Hospitais da região de Lisboa onde para além da caracterização
do ambiente hospitalar quanto às espécies fúngicas
predominantes, foram efetuadas pesquisas dirigidas aos
géneros Aspergillus e Candida. Verificou-se que o controlo
das infeções nosocomiais requer um conhecimento aprofundado
da espécie/estirpe infetante, bem como do seu
padrão de suscetibilidade aos antifúngicos, determinando
assim o risco de infeção tanto para doentes como para os
profissionais de saúde.
The number of nosocomial fungal infections has been increasing dramatically, causing high morbidity and mortality rates in hospitalized patients. The level of environmental fungal contamination is considered an extremely important factor in the incidence and epidemiology of these infections. In a hospital environment, fungal infection may occur through direct or indirect contact with contaminated surfaces or objects, through the hands of health care workers and by ingestion or inhalation of contaminated particles or bioaerosols. Aspergillus and Candida species are the most frequent etiological agents of fungal infections in immunocompromised patients, being frequently isolated from the hospital environment. This paper reports two case- -studies from Hospitals situated in Lisbon. These studies were carried out in order to perform the characterization of the hospital environment in regard to the predominant fungal species, but also to perform directed search of isolates belonging to Aspergillus and Candida genera. These studies demonstrate that control of nosocomial infections requires a deep knowledge of the infecting species/strain, as well as their antifungal susceptibility pattern, thus determining the risk of infection for both patients and health care professionals.
The number of nosocomial fungal infections has been increasing dramatically, causing high morbidity and mortality rates in hospitalized patients. The level of environmental fungal contamination is considered an extremely important factor in the incidence and epidemiology of these infections. In a hospital environment, fungal infection may occur through direct or indirect contact with contaminated surfaces or objects, through the hands of health care workers and by ingestion or inhalation of contaminated particles or bioaerosols. Aspergillus and Candida species are the most frequent etiological agents of fungal infections in immunocompromised patients, being frequently isolated from the hospital environment. This paper reports two case- -studies from Hospitals situated in Lisbon. These studies were carried out in order to perform the characterization of the hospital environment in regard to the predominant fungal species, but also to perform directed search of isolates belonging to Aspergillus and Candida genera. These studies demonstrate that control of nosocomial infections requires a deep knowledge of the infecting species/strain, as well as their antifungal susceptibility pattern, thus determining the risk of infection for both patients and health care professionals.
Description
Keywords
Ambiente Hospitalar Fungos Filamentosos Leveduras Candida Aspergillus Epidemiologia Molecular Infeções Fúngicas Infecções Sistémicas e Zoonoses
Pedagogical Context
Citation
Infecção e Sepsis. 2017;2:13-19.
Publisher
Grupo de Infecção e Sepsis do Hospital de São João
