Publication
Genetic Background and Expression of the New qepA4 Gene Variant Recovered in Clinical TEM-1- and CMY-2-Producing Escherichia coli
| dc.contributor.author | Manageiro, Vera | |
| dc.contributor.author | Félix, David | |
| dc.contributor.author | Jones-Dias, Daniela | |
| dc.contributor.author | Sampaio, Daniel A | |
| dc.contributor.author | Vieira, Luís | |
| dc.contributor.author | Sancho, Luísa | |
| dc.contributor.author | Ferreira, Eugénia | |
| dc.contributor.author | Caniça, Manuela | |
| dc.date.accessioned | 2018-03-07T18:41:22Z | |
| dc.date.available | 2018-03-07T18:41:22Z | |
| dc.date.issued | 2017-10-09 | |
| dc.description.abstract | A new QepA4 variant was detected in an O86:H28 ST156-fimH38 Escherichia coli, showing a multidrug-resistance phenotype. PAβN inhibition ofqepA4-harboring transconjugant resulted in increase of nalidixic acid accumulation. TheqepA4andcatA1genes were clustered in a 26.0-kp contig matching an IncF-type plasmid, and containing a Tn21-type transposon with multiple mobile genetic elements. This QepA variant is worrisome because these determinants might facilitate the selection of higher-level resistance mutants, playing a role in the development of resistance, and/or confer higher-level resistance to fluoroquinolones in association with chromosomal mutations. | pt_PT |
| dc.description.sponsorship | VM was supported by FCT fellowship (grant SFRH/BPD/77486/2011), financed by the European Social Funds (COMPETE-FEDER) and national funds of the Portuguese Ministry of Education and Science (POPH-QREN). The authors thank Fundação para a Ciência e a Tecnologia (FCT) for project grant PEst-OE/AGR/UI0211/2011-2014, Strategic Project UI211-2011-2014 | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Front Microbiol. 2017 Oct 9;8:1899. doi: 10.3389/fmicb.2017.01899. eCollection 2017. | pt_PT |
| dc.identifier.doi | 10.3389/fmicb.2017.01899 | pt_PT |
| dc.identifier.issn | 1664-302X | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/5353 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Frontiers Media | pt_PT |
| dc.relation | EVOLUTIONARY POTENTIAL OF OXYIMINO-BETA-LACTAM RESISTANCE DETERMINANTS IN ANIMALS AND IDENTIFICATION OF NEW ENZYME-INHIBITORS FOR VETERINARY USE | |
| dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fmicb.2017.01899/full | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Antibiotic Resistance | pt_PT |
| dc.subject | QepA4 | pt_PT |
| dc.subject | QuinoloneResistance | pt_PT |
| dc.subject | Genetic Characterization | pt_PT |
| dc.subject | PabN | pt_PT |
| dc.subject | WGS | pt_PT |
| dc.subject | Resistência aos Antimicrobianos | pt_PT |
| dc.title | Genetic Background and Expression of the New qepA4 Gene Variant Recovered in Clinical TEM-1- and CMY-2-Producing Escherichia coli | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | EVOLUTIONARY POTENTIAL OF OXYIMINO-BETA-LACTAM RESISTANCE DETERMINANTS IN ANIMALS AND IDENTIFICATION OF NEW ENZYME-INHIBITORS FOR VETERINARY USE | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F77486%2F2011/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0211%2F2014/PT | |
| oaire.citation.startPage | 1899 | pt_PT |
| oaire.citation.title | Frontiers in Microbiology | pt_PT |
| oaire.citation.volume | 8 | pt_PT |
| oaire.fundingStream | 5876 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isProjectOfPublication | 3b63e7d9-d684-42ae-aff9-36815c617501 | |
| relation.isProjectOfPublication | d3e4188b-642e-4ad7-9a4d-aeea65a89449 | |
| relation.isProjectOfPublication.latestForDiscovery | d3e4188b-642e-4ad7-9a4d-aeea65a89449 |