Browsing by Issue Date, starting with "2017-10-09"
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- Unidade de Avaliação Externa da Qualidade - PNAEQ PortugalPublication . Faria, AnaApresentação do PNAEQ; Áreas e Participantes; Colaborações e Trabalhos desenvolvidos.
- Genetic Background and Expression of the New qepA4 Gene Variant Recovered in Clinical TEM-1- and CMY-2-Producing Escherichia coliPublication . Manageiro, Vera; Félix, David; Jones-Dias, Daniela; Sampaio, Daniel A; Vieira, Luís; Sancho, Luísa; Ferreira, Eugénia; Caniça, ManuelaA new QepA4 variant was detected in an O86:H28 ST156-fimH38 Escherichia coli, showing a multidrug-resistance phenotype. PAβN inhibition ofqepA4-harboring transconjugant resulted in increase of nalidixic acid accumulation. TheqepA4andcatA1genes were clustered in a 26.0-kp contig matching an IncF-type plasmid, and containing a Tn21-type transposon with multiple mobile genetic elements. This QepA variant is worrisome because these determinants might facilitate the selection of higher-level resistance mutants, playing a role in the development of resistance, and/or confer higher-level resistance to fluoroquinolones in association with chromosomal mutations.