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How maternal exposure to aflatoxin B1 impacts the development of progeny intestinal immune system?

2021-09Conference object Open access
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dc.contributor.authorBastos-Amador, P.
dc.contributor.authorDuarte, E.L.
dc.contributor.authorAlvito, P.
dc.contributor.authorAssunção, R.
dc.contributor.authorFerreira, M.
dc.date.accessioned2021-10-29T16:16:23Z
dc.date.available2021-10-29T16:16:23Z
dc.date.issued2021-09
dc.descriptionAbstract publicado em: Abstracts / Toxicology Letters 350S (2021) S245–S246. https://www.eurotox2021.com/wp-content/uploads/EuroTox-2021-Final-abstract-book-by-Elsevier.pdf
dc.description.abstractExposure to toxic contaminants during early-life is associated with the development of diseases. Individuals are exposed to mycotoxins since early stages of life[1]. However how maternal exposure to mycotoxins influences the development and function of the offspring’s immune system remains largely unexplored. Recently, we showed that in utero maternal exposure to micronutrients is critical for the development of the immune system, which sets long term immunity if the progeny[2]. Here we show that presence of aflatoxin B1 in the diet of pregnant murine females affects the development and function of the intestinal immune system. Notably, maternal exposure to AFB1 promoted an increase of overall T cell population, while it also resulted in a selective reduction of cytokine-producing innate lymphoid cells group 2 (ILC2) population in intestine of the progeny. These alterations were associated with decreased expression of Reg3b, Reg3g and Fut2 by the intestinal mucosa of progeny. Thus, these results indicate that maternal exposure to mycotoxins impacts the development of offspring intestinal immune system. ILC2 are critical in intestinal epithelial repair, whether mice exposed to AFB1 display defective tissue damage response needs to be investigated. Also FUT2-dependent fucosylation is key in host–commensal symbiosis suggesting alterations in the intestinal microbiota. Our work reveals that maternal exposure to dietary contaminants such as mycotoxins alters the normal development of intestinal immune system framework of the progeny and may have impact in their immune function.pt_PT
dc.description.sponsorshipThis work was funded by FCT/MCTES through national funds, to earlyMYCO (PTDC/MED-TOX/28762/2017), and CESAM (UIDP/50017/2020+UIDB/50017/2020).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7797
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.eurotox2021.com/wp-content/uploads/EuroTox-2021-Final-abstract-book-by-Elsevier.pdf
dc.subjectMycotoxinspt_PT
dc.subjectAflatoxin B1pt_PT
dc.subjectSegurança dos Alimentospt_PT
dc.subjectComposição dos Alimentospt_PT
dc.subjectAvaliação do Riscopt_PT
dc.subjectSaúde Humanapt_PT
dc.titleHow maternal exposure to aflatoxin B1 impacts the development of progeny intestinal immune system?pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-TOX%2F28762%2F2017/PT
oaire.citation.conferencePlace(online)pt_PT
oaire.citation.title56th Congress of the European Societies of Toxicology (EUROTOX 2021): Toxicology of the next generation, 27 Sep - 1 Oct 2021 (online)pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublication2635814e-db0a-43c5-b745-a2a237efb72e
relation.isProjectOfPublication.latestForDiscovery2635814e-db0a-43c5-b745-a2a237efb72e

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