Publication
Macrophage iron metabolism profile in proatherogenic conditions
| dc.contributor.author | Canonne-Hergaux, François | |
| dc.contributor.author | Marques, Liliana | |
| dc.contributor.author | Negre-Salvayre, Anne | |
| dc.contributor.author | Costa, Luciana | |
| dc.date.accessioned | 2015-09-22T12:52:05Z | |
| dc.date.available | 2015-09-22T12:52:05Z | |
| dc.date.issued | 2015-09 | |
| dc.description.abstract | Atherosclerosis is currently considered as a chronic inflammatory disease, in which the subendothelial accumulation of macrophages and their differentiation in lipid−laden foam cells through the uptake of oxidized LDL (oxLDL) constitute key events in atherogenesis [1]. In such process, iron could constitute a modifiable factor [2] and characterization of the iron metabolism profile of the different macrophages phenotypes present in atherosclerotic lesions may provide insight on their potential protective or proatherogenic role. A new macrophage phenotype (Mox) driven by exposure to oxidized phospholipids was recently described in murine models of atherosclerosis [3]. Herein, we investigated the effect of oxLDL as well as proinflammatory stimuli on macrophage polarization and iron metabolism profile. | por |
| dc.description.sponsorship | This work was supported by Instituto Nacional de Saúde Doutor Ricardo Jorge; INSERM (Institut National de la Santé et de la Recherche Médicale); CNRS (Centre National de la Recherche Scientifique); ANR (Agence Nationale de la Recherche; ANR- 08-GENO-000); Fundação para a Ciência e Tecnologia (Grant SFRH/BD/48671/2008); BioISI (Biosystems & Integrative Sciences Institute). | por |
| dc.identifier.uri | http://hdl.handle.net/10400.18/3129 | |
| dc.language.iso | eng | por |
| dc.publisher | Instituto Nacional de Saúde Doutor Ricardo Jorge, IP | por |
| dc.subject | Determinantes Imunológicos em Doenças Crónicas | por |
| dc.subject | Atherosclerosis | por |
| dc.subject | Chronic Inflammatory Disease | por |
| dc.subject | Iron Metabolism | por |
| dc.title | Macrophage iron metabolism profile in proatherogenic conditions | por |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Hangzhou, China | por |
| oaire.citation.title | 6th Congress of the International Bioiron Society, Biennial World Meeting (BioIron 2015), Zhejiang University, 6-10 September, 2015 | por |
| rcaap.rights | embargoedAccess | por |
| rcaap.type | conferenceObject | por |
Files
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- MACROPHAGE IRON METABOLISM PROFILE IN PROATHEROGENIC CONDITIONS.pdf
- Size:
- 862.75 KB
- Format:
- Adobe Portable Document Format
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: