Macrophage iron metabolism profile in proatherogenic conditions

Canonne-Hergaux, François; Marques, Liliana; Negre-Salvayre, Anne; Costa, Luciana

http://hdl.handle.net/10400.18/3129

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Authors

Canonne-Hergaux, François

Marques, Liliana

Negre-Salvayre, Anne

Costa, Luciana

Abstract(s)

Atherosclerosis is currently considered as a chronic inflammatory disease, in which the subendothelial accumulation of macrophages and their differentiation in lipid−laden foam cells through the uptake of oxidized LDL (oxLDL) constitute key events in atherogenesis [1]. In such process, iron could constitute a modifiable factor [2] and characterization of the iron metabolism profile of the different macrophages phenotypes present in atherosclerotic lesions may provide insight on their potential protective or proatherogenic role. A new macrophage phenotype (Mox) driven by exposure to oxidized phospholipids was recently described in murine models of atherosclerosis [3]. Herein, we investigated the effect of oxLDL as well as proinflammatory stimuli on macrophage polarization and iron metabolism profile.