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No Evidence for Lower Levels of Serum Vitamin D in the Presence of Hepatic Steatosis. A Study on the Portuguese General Population

2018-11Journal article Open access
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dc.contributor.authorLeitão, Jorge
dc.contributor.authorCarvalhana, Sofia
dc.contributor.authorSilva, Ana Paula
dc.contributor.authorVelasco, Francisco
dc.contributor.authorMedeiros, Isabel
dc.contributor.authorAlves, Ana Catarina
dc.contributor.authorBourbon, Mafalda
dc.contributor.authorOliveiros, Bárbara
dc.contributor.authorCarvalho, Armando
dc.contributor.authorCortez-Pinto, Helena
dc.date.accessioned2019-02-22T17:46:13Z
dc.date.available2019-02-22T17:46:13Z
dc.date.issued2018-11
dc.description.abstractIntroduction and aims: Nonalcoholic fatty liver disease (NAFLD) has become highly prevalent, paralleling the pandemic of obesity and diabetes, and represents an important burden. Nutrition knowledge is fundamental, in prevention, evolution and treatment of NAFLD. Association of low serum levels of vitamin D (VD) with several diseases, including NAFLD, has been emphasized in the last decade. We evaluated how serum levels of VD correlate with the presence of hepatic steatosis, and VD intake, in a random sample of the Portuguese adult population. Methods: Participants underwent a dietary intake inquiry, using a semi-quantitative food frequency questionnaire representative of the usual intake over the previous year. Anthropometric measures, blood tests and ultrasound were done. Hepatic steatosis was quantified according to Hamaguchi's ultrasonographic score (steatosis defined by a score ≥ 2). Results: We recruited 789 adult individuals, 416 males (52.7%), mean age of 49.9 ± 17.0 years (18-79). Prevalence of hepatic steatosis was 35.5%, and after exclusion of excessive alcohol consumption, 28.0%. Mean VD serum levels were 26.0 ± 9.8 ng/ml and 68.4% participants had serum VD levels below 30 ng/ml. Mean serum levels of VD were not significantly different between participants with steatosis vs. no steatosis: 25.2±8.7 vs. 26.4±10.3 ng/ml, respectively (p=0.071). There was no correlation between VD serum levels and VD intake, measured by the FFQ, r=0.075 (p= 0.383). Conclusions: In spite of a high prevalence rate, there was no evidence that decreased VD serum levels were associated with hepatic steatosis. No significant correlation was found between VD dietary ingestion and VD serum levels.pt_PT
dc.description.sponsorshipThe present study received grants from: Portuguese Association for the Study of the Liver (APEF); Gilead Foundation and Gilead Genesis; and Roche supplied laboratorial kitspt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Med Sci. 2018 Nov 29;15(14):1778-1786. doi: 10.7150/ijms.26586. eCollection 2018.pt_PT
dc.identifier.doi10.7150/ijms.26586pt_PT
dc.identifier.issn1449-1907
dc.identifier.urihttp://hdl.handle.net/10400.18/5932
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherIvyspring International Publisherpt_PT
dc.relation.publisherversionhttp://www.medsci.org/v15p1778.htmpt_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299420/pdf/ijmsv15p1778.pdf
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHepatic Steatosispt_PT
dc.subjectCommon Populationpt_PT
dc.subjectNonalcoholic Fatty Liver Diseasept_PT
dc.subjectVitamin Dpt_PT
dc.subjectPortuguese Populationpt_PT
dc.subjectDoenças Cardio e Cérebro-vascularespt_PT
dc.titleNo Evidence for Lower Levels of Serum Vitamin D in the Presence of Hepatic Steatosis. A Study on the Portuguese General Populationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1786pt_PT
oaire.citation.issue14pt_PT
oaire.citation.startPage1778pt_PT
oaire.citation.titleInternational Journal of Medical Sciencespt_PT
oaire.citation.volume15pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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