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Activity of Diphenyl diselenide against Aspergillus isolates

2020-02Conference object Restricted access
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dc.contributor.authorMelo, Aryse Martins
dc.contributor.authorPoester, Vanice Rodrigues
dc.contributor.authorMunhoz, Lívia
dc.contributor.authorTrápaga, Mariana
dc.contributor.authorRoca, Beatriz
dc.contributor.authorKlafke, Gabriel Baracy
dc.contributor.authorSabino, Raquel
dc.contributor.authorStevens, David A.
dc.contributor.authorXavier, Melissa Orzechowski
dc.date.accessioned2021-04-23T14:59:07Z
dc.date.available2021-04-23T14:59:07Z
dc.date.issued2020-02
dc.description.abstractOrganoselenium compounds have been showing promising antimicrobial activity against bacteria and some fungal species. Among these compounds, diphenyl diselenide (PhSe)2 is a simple and chemically stable molecule with proven low toxicity to animal hosts. Although the mechanisms of action of this molecule are not totally clear, it has been reported that it has a prooxidative activity for microorganisms, due to glutathione depletion. Given the emergence of azole resistance Aspergillus sp. isolates is a global and rising concern, research towards new molecules with antifungal potential are necessary. Thus, the aim of this study was to evaluate the in vitro susceptibility of Aspergillus spp. clinical isolates to (PhSe)2.pt_PT
dc.description.sponsorshipThe authors are grateful to the Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior (CAPES), grant number 001; PDSE and PRINTCAPES FURG Program; and to the organization of the AAAM2020 for the scholarship to the first author.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7703
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectDiphenyl Diselenidept_PT
dc.subjectAntifungal Susceptibilitypt_PT
dc.subjectAspergilluspt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titleActivity of Diphenyl diselenide against Aspergillus isolatespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLugano, Suiçapt_PT
oaire.citation.title9th Advances Against Aspergillosis and Mucormycosis conference, 27-29 February 2020pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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