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Activity of Diphenyl diselenide against Aspergillus isolates
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Orientador(es)
Resumo(s)
Organoselenium compounds have been showing promising antimicrobial activity against bacteria and some fungal species.
Among these compounds, diphenyl diselenide (PhSe)2 is a simple and chemically stable molecule with proven low toxicity to
animal hosts. Although the mechanisms of action of this molecule are not totally clear, it has been reported that it has a prooxidative
activity for microorganisms, due to glutathione depletion. Given the emergence of azole resistance Aspergillus sp.
isolates is a global and rising concern, research towards new molecules with antifungal potential are necessary. Thus, the aim of
this study was to evaluate the in vitro susceptibility of Aspergillus spp. clinical isolates to (PhSe)2.
Descrição
Palavras-chave
Diphenyl Diselenide Antifungal Susceptibility Aspergillus Infecções Sistémicas e Zoonoses